Résultats de recherche

Au programme 16h00 | Accueil des participants dans le hall de la Faculté de médecine16h30 | Séance anniversaire et inaugurale17h30 | Drink et visite (en groupe) des laboratoiresParticipation externe sur invitation. Une question ?  Contacter Jean-François Colomer : jean-francois.colomer@unamur.be 

The conference is co-organized by the University of Namur, Belgium and Wuhan University of Technology, China and supported by Foshan Xianhu Laboratory and other organisms.More info on the GCMC2025 website...

Abstract Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect—termed the FLASH effect—remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its effectiveness in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PrésidentProf. Stéphane LUCAS (UNamur), SecrétaireProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (Université de Bern)Dr Rudi LABARBE (IBA)

Abstract Due to their unique chemical, physical and photophysical properties, organoboron compounds and in particular triarylboranes play a central role in chemistry and in catalysis. Trivalent neutral boron Lewis acids, which are planar trigonal species, have been shown to exhibit enhanced Lewis acidity and electrophilicities when constrained in a pyramidal trigonal environment. Within the context of the emerging area of geometrically constrained main-group elements, the fundamental experimental and computational investigations of the impact of structural deformation on the physicochemical properties and reactivity of borane derivatives is of interest. This thesis will explore successively the development of geometrically constrained intramolecular FLP and of cationic boron Lewis superacid based on the aza-boratriptycene scaffold, then the synthesis of pyramidalyzed electron-deficient borenium cation with tethered pyridine and NHC ligands embedded in the triptycene scaffold and will finally focus on chiral borenium cations as new Lewis acids. A collaborative work dealing with the combination of the strong 9-sulfonium-10-boratriptycene with hindered Lewis bases is finally performed for developing latent FLP. This work deepens our understanding of the synthesis of constrained boron Lewis acids species, a key step to develop new pyramidal boron Lewis superacids, deblocking new kinds of reactivity in main-group chemistry. For instance, electrophilic Csp2–H borylation reactions of electron-poor aromatics were observed, new unusual binding mode at weakly coordinating anions were discovered and encouraging steps were initiated for reaching new chiral boron-based Lewis acids, opening the path toward new horizons in main-group chemistry.JuryProf. Benoît CHAMPAGNE (UNamur), PrésidentProf. Guillaume BERIONNI (UNamur), SecrétaireProf. Olivier CHUZEL (Aix-Marseille Université)Prof. Raphaël ROBIETTE (UCLouvain)Prof. Stéphane VINCENT (UNamur)

The scientific programme will include 14 academics presenting their work during keynote lectures, a series of oral communications presented by tenured professors, experienced researchers, PhD students or postdoctoral fellows, and two poster sessions. More information and registration

Two talks will be held:Renato OLARTE HERNANDEZ from UNamur will talk about: "Second Quantization in Quantum Chemistry".He will be followed by the talk of Prof. Marc de WERGIFOSSE (UCLouvain) entitled "Natural Response Orbitals and the RespA Procedure". 

Pour leurs activités de recherche, les chercheurs de l'Institut NISM s'appuient sur les équipes des plateformes technologiques, chacune d'entre elles abritant des équipements de pointe, un savoir-faire technique et une expertise pointue. Elles sont accessibles à la communauté scientifique ainsi qu'aux industries.

La recherche au NISM est identifiée par quatre pôles, qui soulignent les principales activités scientifiques menées au sein de l'institut. Chaque pôle est une structure bien définie avec des membres, et il est géré par le représentant du pôle. La structuration des pôles n'empêche pas une coopération permanente entre eux. Il existe en effet une interaction bien établie entre les différents pôles, par le biais de projets communs, de conférences, de séminaires, de cotutelles de thèses de master et de doctorat, entre autres.

Les domaines d'expertise du pôle Matériaux Structurés Fonctionnels (FSM) est divisé en deux domaines interconnectés : le développement d'architectures poreuses en 3D et la fonctionnalisation de nanostructures.

Les projets de recherche, les publications ainsi que les collaborations de l'Institut incluent toutes les catégories de chercheurs.  Portés par des promoteurs académiques, ils mobilisent des chercheurs post-doctorants, des doctorants et même des étudiants de master (étudiants-chercheurs).

Le pôle Modélisation multi-échelle par le calcul à haute performance (HPC-MM) de l'institut NISM vise à partager les techniques, les compétences et les outils de calcul afin de développer de nouveaux matériaux et de prédire leurs propriétés finales.  Il vise également à améliorer les techniques de modélisation et les codes informatiques afin de prendre en compte la majeure partie de la chimie et de la physique de la matière structurée.

Le pôle d’Optique Non-Linéaire et Photonique (NOP) développe des recherches expérimentales, théoriques et numériques dans divers domaines de l’optique, principalement en optique non-linéaire et en photonique, y compris la plasmonique et l’optique quantique.