Search results

Quentin Willot (Biology) has just joined URBE for a two-year post-doctoral position (Marie Sklodowska-Curie Action, supervisor: Alice Dennis) on a project called ChillAnts. This project focuses on the study of adaptation to extreme temperatures in holarctic (trans-Beringian) ant species, from a physiological, ecological and evolutionary point of view. Quentin will present a more technical aspect of his work (Thermal Death Time Curve Modelling).

Thematic sessionsThe day will be organized in two thematic sessions:Cancer metabolismNew advances in cancer therapyInvited speakersProf. Rebecca FITZGERALD, Early Cancer Institute, University of Cambridge, UKDr. Sébastien DUTERTRE, IBMM, University of Montpellier, FranceProf. Sarah-Maria FENDT, Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven, BelgiumDr. Arnaud BLOMME, Laboratory of Metabolic Regulation, GIGA Institute, University of Liège, Belgium Call for communicationsYoung researchers are invited to submit abstracts for oral communications and posters. All topics related to the field of cancer research are welcome. The deadline for abstract submission is April 1, 2025. Organizing committeeProf. Jean-Pierre Gillet - UNamur, NARILIS, Laboratory of Molecular Cancer BiologyProf. Marc Hennequart - UNamur, NARILIS, Laboratory of Cancer metabolismProf. Marielle Boonen - UNamur, NARILIS, Laboratory of Intracellular Trafficking BiologyProf. Benjamin Beck - ULB, IRIBHMProf. Lionel D'Hondt - CHU UCL Namur, Department of Oncology More info

English versionIn the context of an international Chaire Francqui 2024-2025, the Faculty of Computer Science (UNamur) has the honor to receive Professor Arie Van Deursen (TU Delft, Netherlands ) from the 24th to the 27st of March, for a series of lectures on the theme of: “ Explainable Software Engineering ”.The inaugural lecture, entitled “Explainable Software Engineering in the Public Sector”, will be held on the 25th of March 2025, at 6pm at PA02 (Sentier Thomas, 5000 – Namur).French versionAs part of an international Francqui Chair 2024-2025, the Faculty of Computer Science (UNamur) will have the pleasure of welcoming Professor Arie Van Deursen (TU Delft, Netherlands) from March 24 to 27, 2025, for a series of lessons on the theme: "Explainable Software Engineering".The inaugural lesson, entitled "Explainable Software Engineering in the Public Sector", will take place on Tuesday March 25, 2025 at 6:00 pm at PA02 (Sentier Thomas, 5000 - Namur). Explainable Software Engineering in the Public Sector The field of software engineering seeks to devise theories, methods, tools, and techniques that support the development, operation, and evolution of the digital infrastructure modern society relies on. While the software engineering capabilities have advanced substantially over the past decades, it remains challenging to deliver high quality systems in a timely and cost-effective manner. Government system in particular have a weak reputation in this respect.To better understand why, we analyze 125 complex software projects in the public sector in The Netherlands. The projects are described in public reports published by the Advisory Council on IT Assessments (AcICT), which advises the Dutch parliament and cabinet on riks and chances of success in complex Information Technology (IT) projects. The projects span a time period of 10 years, represent a total budget of over 14 billion Euros, and cover such areas as tax collection, social security, pensions, health, traffic control, defense, or water management.We study these reports through the lens of "explainability", focusing on supporting decision making. Furthermore, we reflect on current advances in software engineering, including modern software testing and large language models, in addressing current software engineering challenges. Program INAUGURAL LECTURE: Explainable Software Engineering in the Public Sector - Tuesday 25/03 - 18:00-19:00 - PA02 SESSION 1: Architectural decision making in software engineering - Monday 24/03 - 10:30-12:30 - I33SESSION 2 : Tests as executable explanations - Tuesday 25/03 - 14:00-16:00 - I33SESSION 3: Technical debt, test smells, legacy systems - Wednesday 26/03 - 14:00-16:00 - I33SESSION 4: Artificial Intelligence for Software Engineering - Thursday 27/03 - 10:30-12:30 - I33 About the speaker Arie van Deursen is a professor at Delft University of Technology, where he leads the Software Engineering Research Group. His research interests include software testing, language models for code, trustworthy artificial intelligence, and human aspects of software engineering. He presently serves as chair of the Steering Commmittee of the ACM/IEEE International Conference on Software Engineering (ICSE).He is a member of the Dutch Advisory Council on IT Assessments (AcICT), as well as a member of the Advisory Board of ING Bank The Netherlands. In 2023, he was elected fellow of the Netherlands Academy of Engineering (NAE). Read more Register for the event

English versionIn the context of an international Chaire Francqui 2024-2025, the Faculty of Computer Science (UNamur) has the honor to receive Professor Arie Van Deursen (TU Delft, Netherlands ) from the 24th to the 27st of March, for a series of lectures on the theme of: “ Explainable Software Engineering ”.The inaugural lecture, entitled “Explainable Software Engineering in the Public Sector”, will be held on the 25th of March 2025, at 6pm at PA02 (Sentier Thomas, 5000 – Namur).French versionDans le cadre d’une Chaire Francqui internationale 2024-2025, la faculté d’informatique (UNamur) aura le plaisir de recevoir le Professeur Arie Van Deursen (TU Delft, Pays-bas) du 24 au 27 mars 2025, pour une série de leçons sur le thème: "Explainable Software Engineering".   La leçon inaugurale, intitulée "Explainable Software Engineering in the Public Sector ", se tiendra le mardi 25 mars 2025 à 18h00 au PA02 (Sentier Thomas, 5000 – Namur). Explainable Software Engineering in the Public Sector The field of software engineering seeks to devise theories, methods, tools, and techniques that support the development, operation, and evolution of the digital infrastructure modern society relies on. While the software engineering capabilities have advanced substantially over the past decades, it remains challenging to deliver high quality systems in a timely and cost-effective manner. Government system in particular have a weak reputation in this respect.To better understand why, we analyze 125 complex software projects in the public sector in The Netherlands. The projects are described in public reports published by the Advisory Council on IT Assessments (AcICT), which advises the Dutch parliament and cabinet on riks and chances of success in complex Information Technology (IT) projects. The projects span a time period of 10 years, represent a total budget of over 14 billion Euros, and cover such areas as tax collection, social security, pensions, health, traffic control, defense, or water management.We study these reports through the lens of "explainability", focusing on supporting decision making. Furthermore, we reflect on current advances in software engineering, including modern software testing and large language models, in addressing current software engineering challenges. Program INAUGURAL LECTURE: Explainable Software Engineering in the Public Sector - Tuesday 25/03 - 18:00-19:00 - PA02 SESSION 1: Architectural decision making in software engineering - Monday 24/03 - 10:30-12:30 - I33SESSION 2 : Tests as executable explanations - Tuesday 25/03 - 14:00-16:00 - I33SESSION 3: Technical debt, test smells, legacy systems - Wednesday 26/03 - 14:00-16:00 - I33SESSION 4: Artificial Intelligence for Software Engineering - Thursday 27/03 - 10:30-12:30 - I33 About the speaker Arie van Deursen is a professor at Delft University of Technology, where he leads the Software Engineering Research Group. His research interests include software testing, language models for code, trustworthy artificial intelligence, and human aspects of software engineering. He presently serves as chair of the Steering Commmittee of the ACM/IEEE International Conference on Software Engineering (ICSE).He is a member of the Dutch Advisory Council on IT Assessments (AcICT), as well as a member of the Advisory Board of ING Bank The Netherlands. In 2023, he was elected fellow of the Netherlands Academy of Engineering (NAE). Read more Register for the event

English versionIn the context of an international Chaire Francqui 2024-2025, the Faculty of Computer Science (UNamur) has the honor to receive Professor Arie Van Deursen (TU Delft, Netherlands ) from the 24th to the 27st of March, for a series of lectures on the theme of: “ Explainable Software Engineering ”.The inaugural lecture, entitled “Explainable Software Engineering in the Public Sector”, will be held on the 25th of March 2025, at 6pm at PA02 (Sentier Thomas, 5000 – Namur).French versionAs part of an international Francqui Chair 2024-2025, the Faculty of Computer Science (UNamur) will have the pleasure of welcoming Professor Arie Van Deursen (TU Delft, Netherlands) from March 24 to 27, 2025, for a series of lessons on the theme: "Explainable Software Engineering".The inaugural lesson, entitled "Explainable Software Engineering in the Public Sector", will take place on Tuesday March 25, 2025 at 6:00 pm at PA02 (Sentier Thomas, 5000 - Namur). Explainable Software Engineering in the Public Sector The field of software engineering seeks to devise theories, methods, tools, and techniques that support the development, operation, and evolution of the digital infrastructure modern society relies on. While the software engineering capabilities have advanced substantially over the past decades, it remains challenging to deliver high quality systems in a timely and cost-effective manner. Government system in particular have a weak reputation in this respect.To better understand why, we analyze 125 complex software projects in the public sector in The Netherlands. The projects are described in public reports published by the Advisory Council on IT Assessments (AcICT), which advises the Dutch parliament and cabinet on riks and chances of success in complex Information Technology (IT) projects. The projects span a time period of 10 years, represent a total budget of over 14 billion Euros, and cover such areas as tax collection, social security, pensions, health, traffic control, defense, or water management.We study these reports through the lens of "explainability", focusing on supporting decision making. Furthermore, we reflect on current advances in software engineering, including modern software testing and large language models, in addressing current software engineering challenges. Program INAUGURAL LECTURE: Explainable Software Engineering in the Public Sector - Tuesday 25/03 - 18:00-19:00 - PA02 SESSION 1: Architectural decision making in software engineering - Monday 24/03 - 10:30-12:30 - I33SESSION 2 : Tests as executable explanations - Tuesday 25/03 - 14:00-16:00 - I33SESSION 3: Technical debt, test smells, legacy systems - Wednesday 26/03 - 14:00-16:00 - I33SESSION 4: Artificial Intelligence for Software Engineering - Thursday 27/03 - 10:30-12:30 - I33 About the speaker Arie van Deursen is a professor at Delft University of Technology, where he leads the Software Engineering Research Group. His research interests include software testing, language models for code, trustworthy artificial intelligence, and human aspects of software engineering. He presently serves as chair of the Steering Commmittee of the ACM/IEEE International Conference on Software Engineering (ICSE).He is a member of the Dutch Advisory Council on IT Assessments (AcICT), as well as a member of the Advisory Board of ING Bank The Netherlands. In 2023, he was elected fellow of the Netherlands Academy of Engineering (NAE). Read more Register for the event

English versionIn the context of an international Chaire Francqui 2024-2025, the Faculty of Computer Science (UNamur) has the honor to receive Professor Arie Van Deursen (TU Delft, Netherlands ) from the 24th to the 27st of March, for a series of lectures on the theme of: “ Explainable Software Engineering ”.The inaugural lecture, entitled “Explainable Software Engineering in the Public Sector”, will be held on the 25th of March 2025, at 6pm at PA02 (Sentier Thomas, 5000 – Namur).French versionAs part of an international Francqui Chair 2024-2025, the Faculty of Computer Science (UNamur) will have the pleasure of welcoming Professor Arie Van Deursen (TU Delft, Netherlands) from March 24 to 27, 2025, for a series of lessons on the theme: "Explainable Software Engineering".The inaugural lesson, entitled "Explainable Software Engineering in the Public Sector", will take place on Tuesday March 25, 2025 at 6:00 pm at PA02 (Sentier Thomas, 5000 - Namur). Explainable Software Engineering in the Public Sector The field of software engineering seeks to devise theories, methods, tools, and techniques that support the development, operation, and evolution of the digital infrastructure modern society relies on. While the software engineering capabilities have advanced substantially over the past decades, it remains challenging to deliver high quality systems in a timely and cost-effective manner. Government system in particular have a weak reputation in this respect.To better understand why, we analyze 125 complex software projects in the public sector in The Netherlands. The projects are described in public reports published by the Advisory Council on IT Assessments (AcICT), which advises the Dutch parliament and cabinet on riks and chances of success in complex Information Technology (IT) projects. The projects span a time period of 10 years, represent a total budget of over 14 billion Euros, and cover such areas as tax collection, social security, pensions, health, traffic control, defense, or water management.We study these reports through the lens of "explainability", focusing on supporting decision making. Furthermore, we reflect on current advances in software engineering, including modern software testing and large language models, in addressing current software engineering challenges. Program INAUGURAL LECTURE: Explainable Software Engineering in the Public Sector - Tuesday 25/03 - 18:00-19:00 - PA02 SESSION 1: Architectural decision making in software engineering - Monday 24/03 - 10:30-12:30 - I33SESSION 2 : Tests as executable explanations - Tuesday 25/03 - 14:00-16:00 - I33SESSION 3: Technical debt, test smells, legacy systems - Wednesday 26/03 - 14:00-16:00 - I33SESSION 4: Artificial Intelligence for Software Engineering - Thursday 27/03 - 10:30-12:30 - I33 About the speaker Arie van Deursen is a professor at Delft University of Technology, where he leads the Software Engineering Research Group. His research interests include software testing, language models for code, trustworthy artificial intelligence, and human aspects of software engineering. He presently serves as chair of the Steering Commmittee of the ACM/IEEE International Conference on Software Engineering (ICSE).He is a member of the Dutch Advisory Council on IT Assessments (AcICT), as well as a member of the Advisory Board of ING Bank The Netherlands. In 2023, he was elected fellow of the Netherlands Academy of Engineering (NAE). Read more Register for the event

English versionIn the context of an international Chaire Francqui 2024-2025, the Faculty of Computer Science (UNamur) has the honor to receive Professor Arie Van Deursen (TU Delft, Netherlands ) from the 24th to the 27st of March, for a series of lectures on the theme of: “ Explainable Software Engineering ”.The inaugural lecture, entitled “Explainable Software Engineering in the Public Sector”, will be held on the 25th of March 2025, at 6pm at PA02 (Sentier Thomas, 5000 – Namur).French versionAs part of an international Francqui Chair 2024-2025, the Faculty of Computer Science (UNamur) will have the pleasure of welcoming Professor Arie Van Deursen (TU Delft, Netherlands) from March 24 to 27, 2025, for a series of lessons on the theme: "Explainable Software Engineering".The inaugural lesson, entitled "Explainable Software Engineering in the Public Sector", will take place on Tuesday March 25, 2025 at 6:00 pm at PA02 (Sentier Thomas, 5000 - Namur). Explainable Software Engineering in the Public Sector The field of software engineering seeks to devise theories, methods, tools, and techniques that support the development, operation, and evolution of the digital infrastructure modern society relies on. While the software engineering capabilities have advanced substantially over the past decades, it remains challenging to deliver high quality systems in a timely and cost-effective manner. Government system in particular have a weak reputation in this respect.To better understand why, we analyze 125 complex software projects in the public sector in The Netherlands. The projects are described in public reports published by the Advisory Council on IT Assessments (AcICT), which advises the Dutch parliament and cabinet on riks and chances of success in complex Information Technology (IT) projects. The projects span a time period of 10 years, represent a total budget of over 14 billion Euros, and cover such areas as tax collection, social security, pensions, health, traffic control, defense, or water management.We study these reports through the lens of "explainability", focusing on supporting decision making. Furthermore, we reflect on current advances in software engineering, including modern software testing and large language models, in addressing current software engineering challenges. Program INAUGURAL LECTURE: Explainable Software Engineering in the Public Sector - Tuesday 25/03 - 18:00-19:00 - PA02 SESSION 1: Architectural decision making in software engineering - Monday 24/03 - 10:30-12:30 - I33SESSION 2 : Tests as executable explanations - Tuesday 25/03 - 14:00-16:00 - I33SESSION 3: Technical debt, test smells, legacy systems - Wednesday 26/03 - 14:00-16:00 - I33SESSION 4: Artificial Intelligence for Software Engineering - Thursday 27/03 - 10:30-12:30 - I33 About the speaker Arie van Deursen is a professor at Delft University of Technology, where he leads the Software Engineering Research Group. His research interests include software testing, language models for code, trustworthy artificial intelligence, and human aspects of software engineering. He presently serves as chair of the Steering Commmittee of the ACM/IEEE International Conference on Software Engineering (ICSE).He is a member of the Dutch Advisory Council on IT Assessments (AcICT), as well as a member of the Advisory Board of ING Bank The Netherlands. In 2023, he was elected fellow of the Netherlands Academy of Engineering (NAE). Read more Register for the event

An analysis of voter turnout in October 2024This analysis presents a comparison of voter turnout in Wallonia, Brussels and Flanders. On the one hand, the report identifies the profiles and political attitudes of voters who abstained (representative survey of the Belgian population). On the other hand, the report presents the evolution of abstention and electoral participation according to institutional and political contexts in Wallonia. Particular attention is paid to the increase in blank and invalid votes in Wallonia.Analysis of the effects of electoral reforms since 2018This analysis presents the effects linked to the adoption of gender quotas in communal executives, as well as the effects of the end of the devolutive effect of the top box in Wallonia. These electoral reforms may have had limited effects in some communes (mainly due to a "learning" effect of the new electoral rules). Our report analyzes the effects observed in 2024 and the factors explaining the differences observed between Wallonia's communes.Analysis of the restructuring of the electoral offer in 2024While 2018 had seen a significant increase in the number of lists present at communal polls (notably so-called "citizen" and far-right lists), in October 2024, the number of lists in competition fell significantly. An analysis of official figures describes the evolution of the number and type of lists according to the institutional and political configurations of Wallonia's communes. It focuses in particular on the evolution of typically "local" lists, a Walloon characteristic within European democracies. Practical information L'ArsenalRue Bruno, 11 - 5000 NamurL'Arsenal is a 10-minute walk from Namur train station and the Parliament of Wallonia. Adjacent parking is available free of charge (Rue de l'Arsenal 13, 5000 Namur)Registration required (places are limited - registration deadline: March 3) Program 9:00-13:00: Conference workshop9:00-9:30: welcome and coffee9:30-9:35: presentation of the project by the inter-university consortium9:35-11:40 : presentation of reports and Q&A Analysis of the restructuring of the electoral offer in 2024 Analysis of electoral participation in 2024 Analysis of the effects of electoral reforms in 202411:40-11:50 : closing remarks12:00-13:00: closing lunchContact person For information requests: laura.uyttendaele@unamur.be and jeremy.dodeigne@unamur.be SPW Interior and Social Action

Customer experience at the heart of new technologies - Discover shop+TECH Customer experience is a key concern for companies today, as consumers become ever more connected and demanding. How can we meet these expectations while exploiting technological innovations? The shop+TECH conference, organized on January 30, 2025, invites you to dive into the digital tools capable of radically transforming customer relations, both online and in physical stores.Explore the latest advances in augmented reality (AR) and virtual reality (VR) that are pushing back the boundaries of the shopping experience. These technologies are revolutionizing not only the customer journey, but also the way consumers perceive and appropriate products.On the program: keynote speakersThierry Jourquin: Discover HITT and dive into various concrete use cases created by XRintelligence and other players in the XR ecosystem. An exploration of the current and future applications of extended reality (XR) in retail.Laszlo Arnould, founder of PopulAR: Real-life cases made by the 40k creators of PopulAR's independent community, demonstrating the incredible potential of augmented reality (AR) to enrich the shopping experience, whether online or in physical stores.Jean-Nicolas Vandelac, representing Hoppin (Quebec): Direct from Quebec, he will present their platform focused on augmented tourism, illustrating how AR technology is transforming traditional sectors to offer unique immersive experiences.(To be confirmed) Mrs Ingrid Poncin, researcher at UCL: Thanks to her expertise, she will enrich the Q&A session following the presentations, providing a valuable academic perspective on the future of customer experience and immersive technologies.Why attend?The shop+TECH conference is a unique opportunity to understand how digital is redefining the boundaries between technology and human experience. Whether you're a retail player, innovator or simply curious, this evening will provide you with essential keys to anticipating and accompanying the major transformations in your sector.The evening will close with a questions/answers session and a convivial moment of networking, perfect for exchanging ideas with the speakers and other participants.The +TECH conferences highlight inspiring projects and achievements that combine traditional sectors and new technologies. In 2025, find three unique gatherings: shop+TECH, book+TECH, and money+TECH.Join us for shop+TECH and let yourself be inspired by these new perspectives!

Jury Prof. Benoît MUYLKENS (URVI, Université de Namur), PresidentProf. Carine MICHIELS (URBC, Université de Namur), SecretaryProf. Xavier DE BOLLE (URBC, Université de Namur)Prof. René REZSOHAZY (LIBST, Université catholique de Louvain)Prof. Florian STEINER (Dept. of Molecular and Cellular Biology, Université de Genève)Prof. Germano CECERE (Department of developmental and Stem Cell Biology, Institut Pasteur) Summary In animals, germ cells are often distinguished from somatic lineages at the earliest stages of embryogenesis. In some organisms, germ blastomeres appear to enter a state of transcriptional quiescence. For example, in the worm Caenorhabditis elegans, transcription is activated in somatic blastomeres as early as the 4-cell stage, whereas it is not initiated in germline blastomeres until the 100-cell stage. This transcriptional repression in germ blastomeres has been attributed to the PIE-1 protein, specifically localized in these cells from the first embryonic division. PIE-1 is thought to inhibit the activity of CDK-9, a cyclin-dependent kinase previously considered essential for the phosphorylation of serine 2 (CTD-Ser2) of the C-terminal domain (CTD) of RNA polymerase II and for transcription elongation. However, recent studies, showing that embryogenesis proceeds normally in a mutant strain expressing a CTD in which serines 2 is replaced by an alanine (CTD-S2A) and identifying CDK-12 as the main kinase phosphorylating CTD-Ser2, call this model into question.To study the transcriptome of germline blastomeres in the worm C. elegans, an approach combining cell sorting and RNA sequencing (RNA-seq) was developed. Pilot analyses validated this method on a wild-type strain, enabling its use on a strain in which PIE-1 can be specifically degraded using the Auxin-Inducible Degron (AID) system. This made it possible to examine the effect of PIE-1 depletion on the transcriptome of germline blastomeres revealing that in its absence, germline blastomeres adopt a transcriptional profile close to that of somatic blastomeres, confirming the fundamental role of PIE-1 in preserving germline identity during embryogenesis. In parallel, the fission yeast Schizosaccharomyces pombe was used to analyze the consequences of PIE-1 expression in a heterologous organism. The results showed that PIE-1 by localizing near transcription termination sites induces further transcription by RNA polymerase II beyond the termination site, leading to transcription of intergenic regions. These observations led to the hypothesis that in C. elegans,within germinal blastomeres, PIE-1 might regulate alternative polyadenylation in 3' untranslated regions, producing longer RNA isoforms susceptible to degradation. In the absence of PIE-1, shorter isoforms could be generated, allowing accumulation of somatic transcripts and potentially degradation of maternal mRNAs via somatic protein translation. Although further investigations are required in C. elegans to validate this hypothesis, it provides an innovative conceptual framework for understanding the role of PIE-1, independent of CTD-Ser2 phosphorylation.

Jury Prof. Marielle BOONEN (UNamur), presidentProf. Henri-François RENARD (UNamur), secretaryProf. Claire HIVROZ (PSL University)Prof. Michel GHISLAIN (UCLouvain)Prof. Pierre VAN DER BRUGGEN (UCLouvain)Prof. Ludger JOHANNES (PSL University)Prof. Pierre MORSOMME (UCLouvain) Summary Clathrin-independent endocytosis (CIE) mediates the cellular uptake of endogenous and exogenous cargoes, including bacterial toxins and viruses. Endophilin A3-mediated endocytosis is a specific CIE mechanism that differs from fast endophilin-mediated endocytosis (FEME), with ALCAM and L1CAM being the first confirmed Endophilin A3-specific cargoes. Here, we report ICAM1 as a new Endophilin A3-dependent endocytic cargo. ALCAM and ICAM1 are important components of immune synapses (IS), which are polarized structures formed between immune cells and target cells, such as cancer cells. These molecules transduce essential co-stimulatory signals to T cells to help their effective activation and proliferation. We find that both ALCAM and ICAM1 serve as cargoes for retromer-dependent retrograde transport to the trans-Golgi network (TGN) in cancer cells. Interestingly, disrupting Endophilin A3-mediated endocytosis or retromer-dependent retrograde transport machinery impairs activation of autologous cytotoxic CD8 T cells, possibly by affecting the polarized redistribution of immune synapse components at the plasma membrane. Altogether, our findings demonstrate that CIE and retrograde transport are key pathways in cancer cells that promote the activation of cytotoxic CD8 T cells.

Jury Prof. Yves CAUDANO (UNamur), chairmanProf. André FÜZFA (UNamur), secretaryProf. Dominique LAMBERT (UNamur)Dr. Jérémy REKIER (Observatoire royal de Belgique et UCLouvain)Prof. Dr. Félix FINSTER (Regensburg University) Summary Sounding the Universe with a relativistic solar sailboat or Einstein-Dirac fermionsThe Universe exerts a curiosity on man that is both undeniable and fundamental. To unravel the mysteries of the Cosmos, man is driven to develop two major investigative strategies: direct exploration by sending space probes, and indirect exploration by observing cosmic electromagnetic fields, gravitational waves or particles such as fermions.Following these two strategies, in this thesis we develop, in the first approach (consisting of sending a space probe), a relativistic kinematic and dynamical model of photonic sails (light sails) with arbitrary reflectivity and absorbance, moving in a non-rectilinear manner with the aim of exploring interstellar space. The problem is to determine the sail's trajectory in a Minkowski spacetime, a four-dimensional variety. From detailed calculations, we obtain the sail's universe line in the laser reference frame as a function of the sail's proper time.The second approach applies the Two-State Vector Formalism and weak measurements to a homogeneous, isotropic cosmological framework. By coupling Dirac spinners to classical gravity, we calculate weak values of the energy-impulse tensor, the Z component of spin and pure states. Extending the work of Finster and Hainzl on Einstein-Dirac cosmology, we show that the accelerated expansion of the Universe can be interpreted as a consequence of post-selection. We also demonstrate that weak measurements can amplify signals using simpler equipment, thanks to judicious selection of the initial and final state vectors. In addition, this procedure highlights certain geometric properties of the Cosmos' three-dimensional space, offering a new way of exploring the structure of the Universe.We also examine the mathematical structure on which the Dirac equation rests beyond the usual dimension and signature. This reveals a rich internal symmetry and gives rise to a particularly aesthetic diagrammatic representation. Abstract Probing the Universe with a Relativistic Light Sail or Einstein-Dirac FermionsHumanity's profound curiosity about the cosmos is both undeniable and fundamental. To demystify the Universe, humankind is compelled to develop both direct and indirect probing strategies: direct exploration through physical visits using probes, and indirect exploration by observing cosmic electromagnetic field, gravitational waves and particles such as fermions.Building on these two strategies, this thesis proposes two distinct approaches to probing the Universe. In the first approach, we present a relativistic kinematic and dynamic model of light sails with arbitrary reflectivity and absorptance, undergoing non-rectilinear motion as a method of interstellar exploration. The problem involves solving for the trajectory of the sail in a 4-dimensional Minkowski spacetime manifold. By detailed computation, we derive the worldline of the sail in the laser's frame in the sail's proper time.The second approach applies the Two-State Vector Formalism and weak measurements to a spatially homogeneous and isotropic cosmological framework. Coupling Dirac spinors with classical gravity, we compute weak values of the energy-momentum tensor, the Z-component of spin, and pure states. Extending the work of Finster and Hainzl on Einstein-Dirac cosmology, we demonstrate that the Universe's accelerated expansion can be interpreted as a consequence of post-selection. We also show that weak measurements can amplify signals with simpler equipment by carefully selecting initial and final state vectors. This process also reveals geometric properties of the spacelike three-manifold of the Cosmos, opening new way on probing the structure of the Universe.We explore also the mathematical framework underlying the Dirac equation beyond the standard dimension and signature. This enterprise reveals its symmetrically rich properties and aesthetic diagrammatic representation.