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A delegation from the Université de Namur took part in an exploratory mission to the Université Cheikh Anta Diop (UCAD) in Dakar, Senegal. The aim: to discover the research carried out in the field, meet UCAD researchers and initiate future collaborations between the two institutions.

The Covid-19 pandemic is a human tragedy that has caused millions of deaths worldwide and put our entire society under great strain. But it has also been a tremendous collective moment for many UNamur scientists, whose research continues in an attempt to better understand this disease and its consequences.

The three Belgian scientific experiments selected to be carried out on board the International Space Station (ISS) during astronaut Raphaël Liégeois' mission in 2026 have just been unveiled by the Federal Science Policy Public Service (Belspo). One of them is carried by a team from UNamur for an experiment at the crossroads of biology and physics aimed at analyzing the resistance of the "blob", an atypical unicellular organism.

Target audienceGeneral practitioners (in practice or in training)PharmacistsMedical and pharmacy studentsObjectivesShare and discuss scientific articles relevant to frontline practice in a friendly and caring atmosphereStrengthen skills in critical reading and evidence-based medicineCreate a lasting link between the field and the academic worldFederate an active and committed medico-pharmaceutical community.pharmaceutical communityWhy participate?Because science moves fast, and we all benefit from taking the time to read, understand, and question the literature together. Because quality care starts with shared reflection. And because it's the ideal opportunity to strengthen bridges between disciplines.Location and frequency of meetingsUNamur - Quai22 - 2 times a yearFirst meeting: 5/06/2025 (free with registration)INAMI accreditation required. I want to register

Beautiful victory for Margaux Mignolet, a researcher at the Faculty of Medicine's Unité de Recherche en Physiologie Moléculaire (URPhyM), who wins 1st prize in the Belgian inter-university final of the Ma thèse en 180 secondes (MT180) competition. Her research? To better understand the mechanisms of antibodies active in cases of long COVID. The second prize in this national competition was also won by a candidate from Namur. It was Petra Manja, from the Unité de Recherche en biologie des micro-organismes (URBM), Department of Biology, Faculty of Science, and is pursuing a thesis aimed at understanding resistance mechanisms in the bacterium E. coli. Both are also researchers at the NARILIS Institute.

Abstract Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect-termed the FLASH effect-remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its efficacy in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PresidentProf. Stéphane LUCAS (UNamur), SecretaryProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (University of Bern)Dr Rudi LABARBE (IBA)

Hepatocellular carcinoma is the most common primary liver cancer. Unfortunately, this tumor still has a high mortality rate due to the lack of effective treatments for its most advanced or poorly localized forms. As part of a partnership with the CHU UCL Namur - site de Godinne and with the support of Roche Belgium, researchers in the Department of Biomedical Sciences are trying to understand why liver tumor cells are so resistant to treatment, and to identify therapeutic alternatives to better target them.

On May 10, 2025, Vice-Rector Carine Michiels and Professor Anne-Catherine Heuskin handed over UNamur's cheque at the grand closing evening of Operation Télévie, which this year raised a record €13,351,977 for the Fonds National de la Recherche Scientifique. Télévie funds are used entirely to finance cancer research projects at universities in the Wallonia-Brussels Federation and the Grand Duchy of Luxembourg.

Research seminar co-organized by Louis Carré and Sabina Tortorella as part of the activities of the Esphin Institute, the Department of Philosophy, and the Arcadie Center as well as the Marie Skłodowska-Curie SOCIAL project This seminar sets out to explore contemporary uses of Hegel's practical thought as well as to question its relevance and legacy. Themes central to recent philosophical debates, such as globalization, race, feminism and the Anthropocene, as well as contemporary challenges facing philosophical reflection - such as social justice and ecological transition, state sovereignty in the face of international markets and the emergence of supranational subjects, or the crisis of democracy in the face of the rise of populism and the return of war - may call for a mobilization of Hegelian thought. The aim of this seminar is not necessarily to propose a strictly historical-philosophical reading of Hegelian thought, but rather to seek to take Hegel beyond Hegel himself, by engaging in a reflection on problematics that find their first formulation in him, but that have developed far beyond his conceptual framework, or by questioning his concepts from perspectives that do not necessarily lay claim to Hegelianism. The aim of this approach is to bring Hegel's thought into dialogue with other philosophical traditions and currents of political philosophy, in order to question its ability to shed light on some of the major issues of our time. By questioning its topicality and limitations, this seminar aims to examine what practical Hegelian philosophy can still offer us today, and how it enables us to question our own problems from a renewed angle. While it is unlikely to provide ready-made solutions, it can perhaps help us to ask the right questions and think differently about the tensions of our time.Chiara Magni (Università degli Studi Roma Tre) will speak on the theme: "What rights for the accused and the convicted? Criminal prosecution and human dignity in the light of Hegel's practical philosophy"Link to attend the online seminar Contact: sabina.tortorella@unamur.beThis project has received funding from the European Union's Horizon Europe research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101150961.

Researchers at the Universities of Namur (UNamur), Brussels (ULB) and Liège (ULiège) have just taken a key step towards understanding viral mechanisms. Their study, published in the international scientific journal PLOS Pathogens, focuses on a particular type of molecule produced by viruses, circular RNAs, and presents an innovative bioinformatics tool capable of better identifying them.

Abstract Primarily described as an alarmone, secondary messenger (p)ppGpp, when accumulated, binds to many targets involved in DNA replication, translation, and transcription. In the asymmetrically-dividing a-proteobacterium Caulobacter crescentus, (p)ppGpp has been shown to strongly impact cell cycle progression and differentiation, promoting the non-replicating G1/swarmer phase. Mutations in the major subunits of transcriptional complex, b or b' subunits, were able to display the (p)ppGpp-related phenotypes even in the absence of the alarmone. We identified that the transcriptional holo-enzyme, RNA polymerase (RNAP) is a primary target of (p)ppGpp in C. crescentus. Furthermore, mutations that inactivate (p)ppGpp binding to RNAP annihilated the (p)ppGpp-related phenotypes and phenocopied a (p)ppGpp0 strain. Our RNAseq analysis further elucidated the changes in the transcriptional landscape of C. crescentus cells displaying different (p)ppGpp levels and expressing RNAP mutants. Since the DNA replication initiation protein DnaA is required to exit the G1 phase, we observed that it was significantly less abundant in cells accumulating (p)ppGpp. We further explored its proteolysis under the influence of (p)ppGpp. Our work suggests that (p)ppGpp regulates cell cycle and differentiation in C. crescentus by reprogramming transcription and triggering proteolytic degradation of key cell cycle regulators by yet unknown mechanisms. In Part II, we identified two σ factors belonging to the ECF family that might be involved in this (p)ppGpp-accompanied phenotypes. In Part III, we propose an overlapping role of the ω subunit, RpoZ, and the heat shock subunit, RpoH, in carbon metabolism.JuryProf. Gipsi LIMA MENDEZ (UNamur), PresidentProf Régis HALLEZ (UNamur), SecretaryDr Emanuele BIONDI (CNRS-Université Paris-Saclay)Prof. Justine COLLIER (University of Lausanne)Dr Marie DELABY (Université de Montréal)