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The Elongator complex is involved in the addition of 5'-carboxylmethyluridine (cm5U)-derived modifications to transfer RNAs (tRNAs), thereby influencing the translation of certain messenger RNAs (mRNAs) and helping to maintain the integrity of the proteome. This complex is involved in a variety of biological processes, and is of particular importance in oncology. The identification of chemical inhibitors of Elongator is of significant interest in both basic and pharmaceutical research.Through a yeast screen, this work reveals a potential new role for Elongator and identifies a chemical inhibitor of the complex. This compound presents itself as an interesting candidate as a pharmacological inhibitor, opening up new perspectives for the search for anti-cancer therapies.

The wolf, long banished from our lands, has made a remarkable comeback in Wallonia since 2016. This mysterious being, now protected, arouses as much fascination as fear. Through an exhibition, held as part of the Cultural Project course, third-year history bachelor students have traced the history of the wolf. From April 11 to 27, 2024, the exhibition entitled "Même pas peur! Une évolution de l'image du loup à travers les siècles" invited audiences to plunge into the heart of a historical exploration.

Quentin Willot (Biology) has just joined URBE for a two-year post-doctoral position (Marie Sklodowska-Curie Action, supervisor: Alice Dennis) on a project called ChillAnts. This project focuses on the study of adaptation to extreme temperatures in holarctic (trans-Beringian) ant species, from a physiological, ecological and evolutionary point of view. Quentin will present a more technical aspect of his work (Thermal Death Time Curve Modelling).

With oral and poster presentations by ILEE affiliates. Students and young researchers are particularly invited to present their research and practice their presentation skills in English. The day is also important for ILEE members as it enables them to keep abreast of ongoing projects in different disciplines and to foster collaboration.At the end of the day, the annual general meeting of all members will take place with a summary of the past year's activities and achievements.We are honored to announce that Arnaud Péters, PhD in history and founder of sites_H, will be the keynote speaker!

Thematic sessionsThe day will be organized in two thematic sessions:Cancer metabolismNew advances in cancer therapyInvited speakersProf. Rebecca FITZGERALD, Early Cancer Institute, University of Cambridge, UKDr. Sébastien DUTERTRE, IBMM, University of Montpellier, FranceProf. Sarah-Maria FENDT, Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven, BelgiumDr. Arnaud BLOMME, Laboratory of Metabolic Regulation, GIGA Institute, University of Liège, Belgium Call for communicationsYoung researchers are invited to submit abstracts for oral communications and posters. All topics related to the field of cancer research are welcome. The deadline for abstract submission is April 1, 2025. Organizing committeeProf. Jean-Pierre Gillet - UNamur, NARILIS, Laboratory of Molecular Cancer BiologyProf. Marc Hennequart - UNamur, NARILIS, Laboratory of Cancer metabolismProf. Marielle Boonen - UNamur, NARILIS, Laboratory of Intracellular Trafficking BiologyProf. Benjamin Beck - ULB, IRIBHMProf. Lionel D'Hondt - CHU UCL Namur, Department of Oncology More info

The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) has just published a study in the prestigious journal Nature, listing and assessing the different values we place on nature. Nicolas Dendoncker, professor in the Department of Geography and member of the ILEE Institute at UNamur, is one of the co-authors.

When a tumour develops in an organism, it is very common for the cancer cells to leave the tumour and move to another organ where they proliferate, creating what are known as metastases. This process is an important factor in mortality, as it means that the disease worsens. Hence the interest in better understanding what happens during this phenomenon. This is what the multidisciplinary team of Carine Michiels, researcher at the NARILIS Institute of UNamur, and Davide Bonifazi, researcher at the University of Vienna, did in the framework of the PACMAN research project financed by the FNRS. The results of this study are published in the journal Neoplasia.

In late November, the Mont-Saint-Guibert-based company Cellistic® donated equipment it no longer used to UNamur. By enabling the university to give this equipment a second life, Cellistic is making an important gesture in support of the development of university research.

EMBO Courses and Workshops are selected for their excellent scientific quality and timelines, provision of good networking activities for all participants and speaker gender diversity (at least 40% of speakers must be from the underrepresented gender). Organisers are encouraged to implement measures to make the meeting environmentally more sustainable.Upon registration - More info and registration on the EMBO website.

Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)