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The program 09:30 | Welcome speech and coffee10:00 | Presentation of the platforms11:00 | Group visit of the platforms12:00 | Lunch and networking Pysico-Chemical Characterization (PC²)The PC² platform comprises a wide range of instruments, including: liquid and solid-state nuclear magnetic resonance spectrometers, X-ray diffractometers for single crystals and powders, instruments for analyzing textural properties (nitrogen physisorption, mercury porosimetry, etc.), instruments for analyzing chemical composition (combustion chemical analysis, ICP-OES, etc.), as well as various separation techniques (chromatography, centrifugation, etc.).), instruments for analyzing chemical composition (combustion chemical analysis, ICP-OES, etc.), and various separation techniques (chromatography, centrifugation, etc.). The combination of these techniques with the presence of two research logisticians and a technician dedicated to sample analysis, as well as highly qualified researchers for the development of advanced applications, reflects the strategic intent of this platform. Among these characterization techniques, solid-state NMR and X-ray diffraction are the most advanced and unique characterization tools.Synthesis, Irradiation and Analysis of Materials (SIAM)The SIAM platform specializes in the advanced synthesis and characterization of materials and nanomaterials. It actively contributes to fundamental research in (bio)materials science, particularly in terms of characterizing surfaces, interfaces and ion/material interactions, in collaboration with international university laboratories. SIAM's analytical capabilities enable it to study a wide range of samples from fields as diverse as materials science, life sciences and heritage science. One of SIAM's key assets is its recognized expertise in spectroscopy (XPS and ToF-SIMS), which can be coupled with nuclear analysis (Ion Beam Analysis or IBA). Thanks to state-of-the-art equipment, all support is provided by a highly qualified team in a dynamic of continuous development and innovation. As part of the University of Namur, SIAM is a privileged partner both for academic research projects and for the provision of services to industrial and institutional players.Lasers, Optics and Spectroscopies (LOS)The LOS platform is developing its expertise around optical methods for the study of materials. LOS recently acquired a Raman scattering microscope for the analysis of liquids, powders, solids and thin films, both organic and inorganic. This technique can be used to identify a sample's chemical composition and structure, as well as certain properties of the medium. Raman spectroscopy can be used to characterize polymers, nanomaterials, pharmacological compounds, geological materials, precious stones, heritage objects and food products, to name but a few. In imaging mode, this technique can map the distribution of a compound in a heterogeneous sample, as well as detect traces. Practical information Registration required before November 4, 2025. I want to register Find out more about UNamur's technology platforms Contact Research Administration | Business Developer - Joël Marinozzi : joel.marinozzi@unamur.be

Abstract Primarily described as an alarmone, secondary messenger (p)ppGpp, when accumulated, binds to many targets involved in DNA replication, translation, and transcription. In the asymmetrically-dividing a-proteobacterium Caulobacter crescentus, (p)ppGpp has been shown to strongly impact cell cycle progression and differentiation, promoting the non-replicating G1/swarmer phase. Mutations in the major subunits of transcriptional complex, b or b' subunits, were able to display the (p)ppGpp-related phenotypes even in the absence of the alarmone. We identified that the transcriptional holo-enzyme, RNA polymerase (RNAP) is a primary target of (p)ppGpp in C. crescentus. Furthermore, mutations that inactivate (p)ppGpp binding to RNAP annihilated the (p)ppGpp-related phenotypes and phenocopied a (p)ppGpp0 strain. Our RNAseq analysis further elucidated the changes in the transcriptional landscape of C. crescentus cells displaying different (p)ppGpp levels and expressing RNAP mutants. Since the DNA replication initiation protein DnaA is required to exit the G1 phase, we observed that it was significantly less abundant in cells accumulating (p)ppGpp. We further explored its proteolysis under the influence of (p)ppGpp. Our work suggests that (p)ppGpp regulates cell cycle and differentiation in C. crescentus by reprogramming transcription and triggering proteolytic degradation of key cell cycle regulators by yet unknown mechanisms. In Part II, we identified two σ factors belonging to the ECF family that might be involved in this (p)ppGpp-accompanied phenotypes. In Part III, we propose an overlapping role of the ω subunit, RpoZ, and the heat shock subunit, RpoH, in carbon metabolism.JuryProf. Gipsi LIMA MENDEZ (UNamur), PresidentProf Régis HALLEZ (UNamur), SecretaryDr Emanuele BIONDI (CNRS-Université Paris-Saclay)Prof. Justine COLLIER (University of Lausanne)Dr Marie DELABY (Université de Montréal)

Abstract Estrogens originating from human and animal excretion, as well as from anthropogenic sources such as cosmetics, plastics, pesticides, detergents, and pharmaceuticals, are among the most concerning endocrine-disrupting compounds in aquatic environments due to their potent estrogenic activity. While their effects on fish reproduction are well documented, their impact on development, particularly metamorphosis, remains poorly studied. This hormonal transition, mainly controlled by the thyroid axis, is essential for the shift from the larval to the juvenile stage in teleosts.The effects of two contraceptive estrogens on zebrafish (Danio rerio) metamorphosis were evaluated: 17α-ethinylestradiol (EE2), a synthetic reference estrogen, and estetrol (E4), a natural estrogen recently introduced in a new combined oral contraceptive formulation. Continuous exposure from fertilization to the end of metamorphosis allowed the assessment of morphological changes, disruptions of the thyroid axis, and modifications of additional molecular pathways potentially involved in metamorphic regulation.EE2 induced significant delays and disturbances in metamorphosis, affecting both internal and external morphological traits, confirming its role as an endocrine disruptor of concern. In contrast, E4 did not cause any detectable morphological alterations even at concentrations far exceeding those expected in the environment, indicating a limited ecotoxicological risk. Molecular analyses showed that EE2 strongly affected thyroid signaling and energy metabolism during metamorphosis, whereas E4 induced only minor transcriptional and proteomic changes.This study provides the first evidence that EE2 can disrupt zebrafish metamorphosis and highlights the importance of including this developmental stage in ecotoxicological assessments. The results also suggest a larger environmental safety margin for E4, although further research is needed to clarify the mechanisms linking estrogen exposure to metamorphic regulation.JuryProf. Frederik DE LAENDER (UNamur), PresidentProf. Patrick KESTEMONT (UNamur), SecretaryDr. Sébastien BAEKELANDT (UNamur)Dr. Valérie CORNET (UNamur)Prof. Jean-Baptiste FINI (Muséum National d'Histoire Naturelle, Paris)Dr. Marc MULLER (ULiège)Prof. Veerle DARRAS (KULeuven)

The conference is co-organized by the University of Namur, Belgium and Wuhan University of Technology, China and supported by Foshan Xianhu Laboratory and other organisms.More info on the GCMC2025 website...

On the occasion of the International Day of Women and Girls in Science proclaimed on February 11 by the United Nations General Assembly, and as part of the European alliance European Space University for Earth and Humanity (UNIVERSEH) focusing on the theme of space, discover the testimonies of four women scientists from UNamur working on astronomical themes.

In an ever-changing world, where health, environmental and societal crises are intertwined, it is becoming imperative to rethink health in a global and interconnected approach. It was against this backdrop that the Faculty of Medicine at the University of Namur inaugurated its new "One Health" teaching unit (UE) on Thursday February 06, 2025, in the presence of Minister Yves Coppieters. This initiative, offered to all UNamur undergraduates, aims to train tomorrow's healthcare professionals in a systemic vision, where human, animal and environmental health are considered as one and the same reality.

Helping us to age independently and in good health. This is the aim of Charlotte Beaudart's research into sarcopenia, an age-related disease that can occur as early as the age of 50. The work of the UNamur researcher and member of the Narilis Institute has been rewarded once again, as she has just been awarded the title of "Namuroise of the Year", for the Sciences category!

Founded some 50 years ago, the Laboratoire d'Analyse par Réactions Nucléaires (LARN) in the Department of Physics at the University of Namur is home to a 2MV tandem particle gas pedal named ALTAÏS (Accélérateur Linéaire Tandetron pour l'Analyse et l'Implantation des Solides), in operation since 1999.

Thomas Balligand, now a lecturer at UNamur, combines his passion for basic research with teaching in histology and cytology. After a diverse background in internal medicine and research, notably at Harvard, he is dedicated to training the next generation of scientists while pursuing his work on nanobodies and their potential in immunotherapy. His desire to awaken scientific curiosity in his students illuminates his new role at the university..

A major breakthrough for the health of women on oral contraceptives has been achieved by researchers in Namur. Every year in Europe, more than 22,000 cases of venous thrombosis or embolism occur among contraceptive pill users. A team of researchers from the University of Namur, in collaboration with QUALIblood (spin-off), has conducted an important study, the results of which could transform prescribing recommendations..

Bringing a new drug to market, particularly when it is intended to treat a pediatric or orphan disease, is a journey fraught with pitfalls. The ERAMET project, coordinated by Professor Flora Musuamba Tshinanu, aims to overhaul the assessment procedures, so that regulatory agencies can take innovative technologies into account and thus make more informed choices.

For about a decade, a disease has been attracting the attention of the medical community. Its name: sarcopenia. This condition affects more than 10% of people over the age of 65 and is characterized by a significant loss of muscle mass and strength. Charlotte Beaudart, a member of the Department of Biomedical Sciences and the NARILIS Research Institute, has made a name for herself on the international stage in recent years by contributing to a better understanding of this disease and raising awareness about it.