Learning outcomes

The course aims to present the basic mechanisms of cancer and to outline the different current and future therapeutic approaches.

Content

-Cancer genetics and epigenetics: oncogenes, signalling pathways, tumour suppressor genes, DNA repair mechanisms, epigenetic regulation of gene expression, infectious and environmental agents stem cells, growth factors, microenvironment, angiogenesis, metastasis, cell cycle, apoptosis, autophagy and senescence; -tools for diagnosis, prognosis and response to treatment -mechanisms involved in the genesis of the main cancers: leukemias and lymphomas, myeloma, cancers of the lung, colon, breast, prostate, ovary, pancreas, skin, brain, stomach,... The molecular basis of anti-cancer therapies and the mechanisms of resistance to treatment: surgical, radio- and chemotherapeutic approaches, based on growth factors and cytokines, immunotherapy and anti-tumour vaccines, targeted therapies, oncolytic viruses, etc.

Teaching methods

Course/seminar

Assessment method

Written and oral examination

Sources, references and any support material

Molecular Basis of Cancer (Expert Consult - Saunders Elsevier) Mendelsohn, Howley, Israel, Gray and Thompson eds. The Biology of Cancer (Garland Science) Weinberd ed

Language of instruction

English
Training Study programme Block Credits Mandatory
Master in Biochemistry and Molecular and Cell Biology Finalité approfondie 2 2 No
Master in Biochemistry and Molecular and Cell Biology Finalité didactique 2 2 No
Master in Biochemistry and Molecular and Cell Biology Finalité spécialisée 2 2 No
Master in Biomedical Sciences Finalité spécialisée en recherche clinique 2 2 No
Master in Biomedical Sciences Finalité spécialisée en recherche préclinique 2 2 No