Learning outcomes

This Learning Unit is divided into two parts:
Part I concerns characterisation techniques related to the field of materials
Part II concerns the techniques for characterising biomacromolecules such as proteins.
Building on the knowledge gained from the Bac 2 and 3 courses and in particular from the Physical Chemistry (spectroscopy and dynamics), Biochemistry and Biological Chemistry courses, this course provides students with a mastery of the most commonly used techniques for the characterisation of solid state materials and biomacromolecules.
At the end of the course, the student will be able to :
• Understand the principles of solid state MNC (SAM, CP, DE...)
• Predict the appearance or analyse a 29Si, 13C, 27Al solid state NMR spectrum for a number of materials
• To have an overview of the potential of the MNC in its solid state
• Understanding the principles of IR and Raman vibrational spectroscopy
• Predict the appearance or analyse typical IR and Raman spectra
• Describe the use of probe molecules (especially for characterising the acidity of solids).
• Furthermore, at the end of the course the student will know the advantages and limitations of each method and will be able to identify the most appropriate technique(s) for the characterisation of a particular property of a biomacromolecule (protein).

Goals

This course aims to provide the necessary foundation to enable students to analyse the structure of inorganic or organic/inorganic solids using a combination of spectroscopic analytical methods. The course also aims to show students the usefulness of various analytical methods for the characterisation of biomacromolecules.
The use of examples from recent papers allows students to see the link with current research in several fields. At the end of the course the student will be able to identify the most appropriate technique(s) for the structural characterisation of a given material and/or biomacromolecules.
The solid state NMR labs will be organised in collaboration with Dr. Luca Fusaro.

Content

See table of contents

Table of contents

For the first part :

1. Introduction. Characterization: a portfolio of modern methods

2. Classification of the most used techniques

3. Solid State Nuclear Magnetic Resonance (NMR). Mainly 29Si, 27Al, 13C and some specific applications concerning 1H NMR.

4. Other important nuclei in materials chemistry: an overview

5. Electron Paramagnetic Resonance (EPR)

6. Fourier Transform IR (FTIR) and Raman Spectroscopy (RS) applied to materials chemistry: silicates, aluminosilicates, metal and metal oxides, carbon nanostructures

 

For the second part :

1. Introduction et rappels

2. Application de méthodes spectroscopiques

3. Mise en œuvre de méthodes de diffusion

4. Application de méthodes calorimétriques

5. Aperçu de nouvelles technologies

6. Complémentarité des différentes techniques : études de cas

 

 

Assessment method

The teaching unit consists of two learning activities: the theoretical course and the practical work
- the theoretical course
The SCHIM104 teaching unit is composed of two parts, the evaluation of the learning activity "theoretical course" will be done on each of these two parts on the same day. This is a written examination of a maximum duration of 3 hours based on open questions and/or reflection problems. To validate the credits of the course, the student must obtain a weighted average mark of at least 10/20. Each part will count for 50% of the final grade. To validate the credits associated with the unit, it will be necessary to pass each part.
- practical work (laboratories) (TP) For part I :
A part of the practical work will be dedicated to a small group work supervised by an assistant. This work will include the critical analysis of different solid state characterisation techniques. This learning activity will be assessed and the final grade will be acquired at the end of the corresponding activity. In the event of an examination in a second session, the grade acquired will be carried forward.
To validate the credits for Part I of the course, the student must obtain a weighted average mark of at least 10/20.
The weighted average for the learning unit is calculated as follows: written exam in session (80%), final grade acquired for TP (20%).
For Part II :
Lab activities are compulsory and active participation will be assessed.
The evaluation modalities may be modified if the health situation (COVID-19) requires it.
In the event of changes to the assessment and/or teaching methods, students will be informed in advance via WebCampus".

Sources, references and any support material

see course PowerPoint

Language of instruction

Français