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Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

Initiated in 1969 by Pullmann and Del Re, the congress is an annual meeting to promote collaboration and friendship between Latin-speaking theoretical chemists. In its early years, European researchers were the main contributors. Subsequently, the Latin American community has made a major contribution, with the emergence of teams whose international reputation now extends far beyond our own community.We are delighted to be holding this meeting at the University of Namur, 55 years after the first CHITEL was organised in Paris, France. We are sure that this 2024 edition will once again be an opportunity to take advantage of the good humour and dynamism of Latin to encourage, develop and strengthen scientific exchanges.We look forward to welcoming you at the University of Namur,The CHITEL 2024 Local Organising Committee. Website

Abstract Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect-termed the FLASH effect-remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its efficacy in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PresidentProf. Stéphane LUCAS (UNamur), SecretaryProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (University of Bern)Dr Rudi LABARBE (IBA)

Welcome to the 1ʳᵉ MG-ERC conference This conference, linked to the research themes of the Chemistry Department, aims to bring together around 100 researchers working in the fields of heteroatom chemistry, coordination chemistry, catalysis, and inorganic chemistry. It represents a real novelty in Belgium in terms of the areas covered, and will enable participants to discover new concepts, ideas and trends in these recent areas of research in chemistry. Here is the list of speakers, who are world experts in their fieldsDr. Daniël Broere (Utrecht University, Netherlands)Prof. Agnieszka Nowak-Król (Universität Würzburg, Germany)Dr. Antoine Simonneau (Université Paul-Sabatier, Toulouse, France)Prof. Dr. Sebastian Riedel (Freie Universität, Berlin, Germany)Dr. Arnaud Voituriez (Université Paris-Saclay, France)Prof. Dr. Alessandro Bismuto (Universität Bonn, Germany)Dr. Christian Hering-Junghans (Leibniz-Institut für Katalyse, Germany)Prof. Connie Lu (Universität Bonn, Germany)Prof. Simon Aldridge (University of Oxford, UK)Dr. Ghenwa Bouhadir (Université Paul-Sabatier, Toulouse, France)Prof. Dr. Viktoria Däschlein (Universität Bonn, Germany)Prof. Viktoria Däschlein-Gessner (Ruhr-University of Bochum, Germany)Dr. Jennifer A. Garden (University of Edinburgh, UK)Prof. Muriel Hissler (Université de Rennes, France)Prof. Jean-François Paquin (Université de Laval, Canada) More information and registration

Program 8:50 | Welcome, registration, and poster setup9:20 | Welcome speechFirst morning session 9:30 | Vladimir N. Uversky - University of South Florida, USA - "Dancing protein clouds: strange biology and chaotic physics of intrinsically disordered proteins" 10:15 | Marie Skepö - Lunds Universitet, Sweden - "Structural and conformation properties of IDPs: computer simulations in combination with experiments" 11:00 | Coffee breakSecond morning session11:30 | Peter Tompa - Vrije Universiteit Brussel, Belgium - "Fuzzy interactions of IDPs driving biomolecular condensation"12:15 | Sonia Longhi - Aix-Marseille Université, France - "Intrinsic disorder, phase transitions, and fibril formation by the Henipavirus V and W proteins"13:00 | Lunch and poster sessionAfternoon session14:30 | Sigrid Milles - Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany - "Intrinsically disordered proteins in endocytosis: an NMR and single molecule fluorescence perspective"15:15 | Jean-François Collet - Université Catholique de Louvain, Belgium - "How disorder controls the transport of lipoproteins in the cell envelope of Gram-negative bacteria" 16:00 | Closing speech16:10 | Networking Beer Time at "Le Chapitre"VenueUniversity of Namur, auditorium Pedro Arrupe (PA02), rue de Bruxelles, 65-67 - 5000 Namur (#21 on the campus map) Download the programme (PDF) Download the campus map Registration guidelines Registration feeStudents (PhD students included): 25 €Seniors: 40 €Payment - Bank transferPayable before 6 December on the account:Name: Université de Namur - ASBLIBAN: BE10 2500 0740 2704BIC: GEBABEBBPlease mention your name/CPO4136330 /e-mail in the payment communication. Abstract guidelines Send us your abstract before 6 December by email: pdid.meeting@unamur.beFormat: Word document, maximum 1 page A4, Times New Roman  Registration All deadlines (registration, payment, abstracts) : 6 December 2024

will take place from September 2 to 6, 2024 at the Gîte du domaine d'Haugimont (owned by the University of Namur) and will deal with medieval manuscripts in their material and historical aspects (parchment and ink manufacture). The event is aimed at historians, archaeologists and researchers in the physical and chemical sciences. Participation is free for doctoral students attached to FNRS doctoral schools in the disciplines concerned. At the crossroads of archaeology, history and the exact sciences, this colloquium-workshop will give the floor to three speakers (a physicist, a chemist and a historian) who will present the interdisciplinary research they are conducting together in this field. Workshops on parchment reproduction, inks and writing materials will be held each day.More information on the event .

The program 09:30 | Welcome speech and coffee10:00 | Presentation of the platforms11:00 | Group visit of the platforms12:00 | Lunch and networking Pysico-Chemical Characterization (PC²)The PC² platform comprises a wide range of instruments, including: liquid and solid-state nuclear magnetic resonance spectrometers, X-ray diffractometers for single crystals and powders, instruments for analyzing textural properties (nitrogen physisorption, mercury porosimetry, etc.), instruments for analyzing chemical composition (combustion chemical analysis, ICP-OES, etc.), as well as various separation techniques (chromatography, centrifugation, etc.).), instruments for analyzing chemical composition (combustion chemical analysis, ICP-OES, etc.), and various separation techniques (chromatography, centrifugation, etc.). The combination of these techniques with the presence of two research logisticians and a technician dedicated to sample analysis, as well as highly qualified researchers for the development of advanced applications, reflects the strategic intent of this platform. Among these characterization techniques, solid-state NMR and X-ray diffraction are the most advanced and unique characterization tools.Synthesis, Irradiation and Analysis of Materials (SIAM)The SIAM platform specializes in the advanced synthesis and characterization of materials and nanomaterials. It actively contributes to fundamental research in (bio)materials science, particularly in terms of characterizing surfaces, interfaces and ion/material interactions, in collaboration with international university laboratories. SIAM's analytical capabilities enable it to study a wide range of samples from fields as diverse as materials science, life sciences and heritage science. One of SIAM's key assets is its recognized expertise in spectroscopy (XPS and ToF-SIMS), which can be coupled with nuclear analysis (Ion Beam Analysis or IBA). Thanks to state-of-the-art equipment, all support is provided by a highly qualified team in a dynamic of continuous development and innovation. As part of the University of Namur, SIAM is a privileged partner both for academic research projects and for the provision of services to industrial and institutional players.Lasers, Optics and Spectroscopies (LOS)The LOS platform is developing its expertise around optical methods for the study of materials. LOS recently acquired a Raman scattering microscope for the analysis of liquids, powders, solids and thin films, both organic and inorganic. This technique can be used to identify a sample's chemical composition and structure, as well as certain properties of the medium. Raman spectroscopy can be used to characterize polymers, nanomaterials, pharmacological compounds, geological materials, precious stones, heritage objects and food products, to name but a few. In imaging mode, this technique can map the distribution of a compound in a heterogeneous sample, as well as detect traces. Practical information Registration required before November 4, 2025. I want to register Find out more about UNamur's technology platforms Contact Research Administration | Business Developer - Joël Marinozzi : joel.marinozzi@unamur.be

The conference is co-organized by the University of Namur, Belgium and Wuhan University of Technology, China and supported by Foshan Xianhu Laboratory and other organisms.More info on the GCMC2025 website...

The IBAF Meetings have been organized since 2003, every two years since 2008, by the Ion Beams Division of the French Vacuum Society (SFV), the oldest national vacuum society in the world, which celebrated its 80th anniversary in 2025.As in previous editions, IBAF 2026 will offer a rich and varied program with guest lectures, oral and poster presentations, and technical sessions. All this will be complemented by an industrial presence to promote exchanges between research and innovation. The conference will cover a wide range of topics, from ion beam instruments and techniques to the physics of ion-matter interactions, including the analysis and modification of materials, applications in the life sciences, earth and environmental sciences, and heritage sciences. More information on the IBAF2026 website

AbstractIn CO2-rich atmospheres such as that of Venus, the study of water vapor requires the use of H2O collision parameters for CO2. However, due to a lack of data, models still use collision parameters for air to estimate the abundance of water vapor in this type of atmosphere. In this thesis, new experimental laboratory measurements of the collision parameters of H2O, HDO, and D2O by CO2 were carried out. These were then used as the basis for dedicated theoretical calculations. Their impact was evaluated using radiative transfer simulations applied to the atmosphere of Venus, under conditions close to those of future observations by the European EnVision mission. The results clearly show that using collision parameters for air instead of CO2 can lead to an overestimation of nearly 40% of the abundance of water vapor in the mesosphere and to inversion difficulties in the troposphere. This work thus provides essential elements for improving the spectral analysis of CO2-rich atmospheres.JuryDr. Ha TRAN (Sorbonne University), ChairProf. Muriel LEPÈRE (University of Namur), SecretaryDr. Emmanuel MARCQ (University of Versailles)Dr. David JACQUEMART (Sorbonne University)Dr. Laurence RÉGALIA (University of Reims)Dr. Séverine ROBERT (Royal Institute for Space Aeronomy, Belgium)

In line with its predecessors, ICEL 2026 will provide an excellent opportunity for the intellectual and social exchanges that keep our community closely connected. It will bring together participants from all over the world involved in the research, development, and manufacturing of emissive materials. A wide array of subjects will be explored, offering a comprehensive perspective on contemporary advances in these fields. We extend a warm invitation for the dissemination of recent breakthroughs in related topics, with a particular emphasis on fostering the active participation of young and motivated researchers.We especially expect to cover the following topics:Thermally Activated Delayed Fluorescence emittersRadical emittersOrganometallic complexesPerovskitesLasingCircularly polarized luminescenceLight emission from exciplexesGreen- and biophotonicsComputational modeling of light-emitting materialsAll practical information (registration, abstract submission, and accommodation) is available on the ICEL2026 website. Access the ICEL2026 website