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Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

Initiated in 1969 by Pullmann and Del Re, the congress is an annual meeting to promote collaboration and friendship between Latin-speaking theoretical chemists. In its early years, European researchers were the main contributors. Subsequently, the Latin American community has made a major contribution, with the emergence of teams whose international reputation now extends far beyond our own community.We are delighted to be holding this meeting at the University of Namur, 55 years after the first CHITEL was organised in Paris, France. We are sure that this 2024 edition will once again be an opportunity to take advantage of the good humour and dynamism of Latin to encourage, develop and strengthen scientific exchanges.We look forward to welcoming you at the University of Namur,The CHITEL 2024 Local Organising Committee. Website

NHNAI - New Humanism at the time of Neurosciences and Artificial Intelligence

Colloques 14/11/2024 | The Emergence of ConsciousnessInterdisciplinary colloquium organized by ESPHIN (UNamur's Espace Philosophique), with the collaboration of the Centre Universitaire Notre-Dame de la Paix (cUNDP), the Louvain Institute of Biomolecular Science and Technology,and Louvai4evolution (UCLouvain).This free colloquium is aimed at:Specialists, students or PhD students from various disciplines: neuroscience, biology, anthropology, medicine, psychology, philosophy, ethics, computer science, robotics, mathematics, ...People with a passion for interdisciplinarity;Humanists and the curious.Location : Faculty of Philosophy and Letters, rue Grafé 1, Local L22Learn more Ecology of life" seminars It's obvious to anyone paying attention to the paths taken by a growing number of 21st century thinkers: these paths lead to the living! Whether it's called "ecophilosophy", "ecoanthropology", "ecosophy" or "ecopolitics", this way of thinking about the living is occupying a growing place not only in the media and publications of all kinds, but also in concrete actions in a variety of fields.Fashion? Ephemeral trend? Collateral effect of "transitionism" tinged with ambient catastrophism? A new attempt at ecological rebellion? The seminars to which we invite you are intended to be a meeting place - an ecosystem - at the heart of which we will resonate with founding texts of this current that integrates nature, environment, milieu, human and non-human, and straddles the worn-out dualisms of our modern tradition. In other words, we propose to read together some key texts by authors who have attempted to draw lessons from their authentic encounters with other living beings.Program 2024-2025 | At the Roots of the HumanOn December 13 2024 from 2:00 pm to 4:00 pm (intervention, discussions and convivial moment). Quentin HIERNAUX will introduce plant philosophy and tell us about Humboldt's "Tableau physique des Andes" and his equinoctial geography of plants.On February 28, 2025 from 2:00 to 4:00 pm (intervention, discussions and convivial moment), Jean-Baptiste VUILLEROD will address the following theme: Naturphilosophie du végétal : Goethe, Schelling, Humboldt.OnApril 11, 2025from 2:00 to 4:00 pm (intervention, discussions and convivial moment), Roland CAZALIS will share his biologist's point of view on the plant world.Introducing the subjectIf we were to take stock of the history of mankind, one trend would certainly stand out: that of a utilitarian relationship with the non-human that continues to grow, and consequently that of a widening gap between the human and the rest.Humanity, however, has its roots in a living environment that cultivates many other relationships than those we currently privilege, which are dominated by instrumental rationality. Sounding out these forgotten relational universes, without which it is increasingly difficult to think about the human, is one aim of this seminar, which this year will invite you to encounter the plant.Last year we turned our attention to the communal dimension of living things, starting with the work of Aldo Leopold. In particular, the American forester challenged us with a question from which we should never stray: "just what and whom do we love?". His answer, in the middle of the last century, already confirmed the trend evoked above: "Certainly not the soils, which we allow to be scavenged towards the estuaries. Certainly not the waters, which we assume have no other function than to power turbines, carry barges and carry away garbage. Certainly not plants, whose entire communities we exterminate without batting an eyelid. Certainly not the animals, from which we have already extirpated many of the largest and most magnificent species.". In the face of this lack of consideration for what is not us, the earth ethic proposed by Leopold "modifies the role of homo sapiens, who, from conqueror of the earth-community, becomes a full member and citizen of it". It is thus an ethic that "implies respect for other members as well as for the community as such", and "man is ultimately only a member of a biotic team" ("The Ethics of the Earth", in Almanac of a Sand County).To help us rediscover this vital sense of community, this year we'll turn to plant lifestyles: those living things that maintain intimate relationships with light, air, water and everything we call "soil". How can we let ourselves be instructed by the plants without which we could not exist? "By making possible the world of which they are part and content, plants destroy the topological hierarchy that seems to reign in the cosmos. They demonstrate that life is a breaking of the asymmetry between container and content. When there is life, philosopher Emanuele Coccia continues, the container lies within the content (and is therefore contained by it) and vice versa. The paradigm of this reciprocal imbrication is what the ancients already called breath (pneuma). To blow, to breathe, means in effect to have this experience: that which contains us, the air, becomes contained within us and, conversely, that which was contained within us becomes that which contains us." (The Life of Plants).The Tableau Physique (1807) by Alexander von Humboldt:

Board members President: Nicolas Monseu-Van CleemputVice-president: Marie d'Udekem-GeversPhilosophy department representative: Laura RizzerioScience-Philosophies-Society Department representative: Geoffroy de BrabanterAssociate member representative: Bertrand HespelSecretariat: Vénonique OroseWebsite manager: Nathanaël Laurent See all members

While still only a dream, the quantum computer is the subject of intense research. The Artemis project, funded by the European Union (EU) and involving UNamur, aims to develop new sources of single photons, and thus lay the technological foundations. A member of the project, physicist Yves Caudano hopes, at the same time, to further explore the foundations of quantum physics.

ECOBAT is an EOS project (FNRS/FWO) that brings together four universities: UCLouvain, KULeuven, the University of Bonn (Germany), and the University of Namur. This consortium currently mobilizes some twenty researchers at all levels (Masters, PhD students, post-docs, promoters), including Dr. Pierre Beaujean, under the supervision of Professor Benoît Champagne..

At a time when bacterial resistance to antibiotics is a public health problem, Professor Stéphane Vincent's team is currently developing dynamic constitutional frameworks (Dynamic Constitutional Frameworks, DCF): a molecular system that would be able to break down certain resistances and thus deliver antibiotics as close as possible to pathogens.

Laura Gagliardi is a renowned international researcher at the University of Chicago, recognized for her pioneering contributions to theoretical and computational chemistry, particularly in the study of reticular materials such as metal–organic frameworks (MOFs). The Solvay/Syensqo Chair in Chemistry honors chemists who have made exceptional advances in their fields. As part of this distinction, Professor Gagliardi delivered a series of lectures at several Belgian universities, including a seminar at the University of Namur, Department of Chemistry.

As part of its seminar, Centre Arcadie will be pleased to welcome Igor Krtolica for a session devoted to his book Romain Gary. De l'humanisme à l'écologie, Gallimard, 2025.Maître de conférences en philosophie à l'Université de Picardie Jules-Verne, junior member of the Institut universitaire de France, Igor Krtolica is the author (in addition to the work to be discussed) of Gilles Deleuze (PUF, coll. "Que sais-je? ", 2015), of Gilles Deleuze et Félix Guattari : Une philosophie des devenirs-révolutionnaires(Éditions Amsterdam, 2024) and of a commentary on an extract from Romain Gary's Les Racines du ciel entitled Antifascism, humanism and ecology (PUF, coll. "Classiques de l'écologie", 2025).After a presentation of the work, Igor Krtolica will be interviewed by Jean-Baptiste Vuillerod and Thibault De Meyer.Free admission. All welcome.Book presentation 1956: the Prix Goncourt is awarded to Racines du ciel, a novel whose hero, Morel, fights against the extermination of elephants in an Africa struggling for independence. Romain Gary described it as the first ecological novel. Ecology enabled him to resolve the unbearable political contradiction in which the post-war West finds itself: the impossibility of believing in man, the impossibility of giving up believing in man. How can we continue to give meaning to the idea of civilization? If we are to maintain the humanist ideal, we need to wage a battle in which man is no longer at the center. Such is the paradox explored here. This literary and philosophical essay reveals the complexity of Romain Gary's thought, his constant irony and humor, his contradictions, his rejection of dogmatism. And its modernity: ahead of his time, the novelist anticipated the controversies driving contemporary ecological thinking, where the human being is only a part of nature, but where nature itself becomes inseparable from history, society and politics. This previously unpublished synthesis of Romain Gary's work is an original analysis of the tension between humanist commitment and ecological cause.. Toutes les activités du Centre Arcadie

As part of its seminar, Centre Arcadie will be pleased to welcome Jeanne Etelain for a session devoted to her book Zones. Terre, sexes et science-fiction, Flammarion, 2025.Jeanne Etelain, PhD from New York University and Université Paris-Nanterre, teaches philosophy and contemporary theory at the École supérieure des Beaux-Arts de Montpellier.After a presentation of the book, Igor Krtolica will be interviewed by Jean-Baptiste Vuillerod and Thibault De Meyer.After a presentation of the book, Jeanne Etelain will be interviewed by Ludovic Dubois, Nathalie Grandjean and Sébastien Laoureux.Free admission. Welcome to all.Book presentation Zone: this ubiquitous term nevertheless remains elusive. In a stunning conceptual investigation at the crossroads of geography, psychoanalysis and science fiction, Jeanne Etelain explores how "zone" has become central to understanding space, in the contemporary context of a crisis in the planet's conditions of habitability. The zone thus emerges as a spatial modality that defies habitual categories, confronting us with space's power to act, whether it's nature, the Earth or the body. All Centre Arcadie activities

Conference organized by Centre Arcadie and the Department of Philosophy as part of the "Philosophie du cinéma" course and the "Cultures et pensées cinématographiques" Specialization Master's degree.Dork Zabunyan is Professor of Film Studies at Université Paris 8 Vincennes-Saint-Denis. His publications include Les Cinémas de Gilles Deleuze (Bayard, 2011), L'Insistance des luttes - Images, soulèvements, contre-révolutions (De l'incidence éditeur, 2016), Foucault va au cinéma (Bayard, 2011) with Patrice Maniglier, Jacques Rancière et le monde des images(Mimesis, 2023).In 2020 he published Fictions of Trump. Puissances des images et exercices du pouvoir(Le point du jour). In this conference, the aim will be to take up this work in the context of Trump's second term.Presentation of the workDonald Trump's body is almost everywhere, outside us, on our screens, caught up in information channels that disseminate still and moving images of him. He is also present within us, more or less floating, in the minds of his detractors and supporters alike. The 45th President of the United States of America is not, however, the book's only subject. Based on his countless audiovisual representations, both before and after his election, the aim here is to explore the function of images in the exercise of power today, the stories they tell and the discourses they condition. Two questions run through this essay: what is this strange love of power, conveyed by images of an authoritarian leader, to which individuals who have no interest in voting for him adhere? What filmic counter-fires, real or imagined, are likely to mobilize the powers of images to evade this power, or even to thwart it? All Centre Arcadie activities