New clues to break through Brucella's armour
A team of microbiology researchers from UNamur has just published in the journal Nature Communications. The work focuses on the Brucella bacterium that causes Brucellosis, a disease that infects livestock and can be transmitted to humans. This research aims to better understand the molecular mechanisms of the bacterium's growth in order to better combat it.
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Public defense of doctoral thesis in Physical Sciences - Andrea Scarmelotto
Abstract
Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect-termed the FLASH effect-remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its efficacy in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PresidentProf. Stéphane LUCAS (UNamur), SecretaryProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (University of Bern)Dr Rudi LABARBE (IBA)
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Partnership with the Entre-Sambre-et-Meuse National Park
With its expertise in the field of geology and biodiversity conservation, the UNamur is one of the partners of the new Entre-Sambre-et-Meuse National Park designated by the Walloon Government. Alongside the other actors and promoters of the project, the UNamur will make its knowledge and experience available to enhance and preserve this exceptional natural heritage!
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Participatory funding: Specularia, experimental archaeology project
The Department of Art History and Archaeology of UNamur is participating for the first time in an experimental archaeology project, within the framework of a doctoral thesis on the production of glass in the Roman period. Conducted in partnership with Malagne, the Rochefort archaeopark, the Specularia project aims to gain a better understanding of the reality of the gestures and techniques of Gallo-Roman craftsmen and to scientifically validate hypotheses that are still debated today. To carry out this experiment, the Department of Art History and Archaeology is launching its first participatory funding.
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Specularia" wins US film awards
The documentary produced as part of the experimental archaeology research project, "Specularia", wins an award at an American festival, organized by the University of Pittsburgh and the University of South Carolina!
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AGC Glass supports the Specularia experimental archaeology project
This is a first at the UNamur: a team of archaeologists will soon be testing an experimental protocol to reproduce the process of shaping glass in Roman times. Entitled Specularia (Latin for "glass"), this project has the support of several associations and companies, including AGC Glass Europe.
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Axel Tixhon, scientific guarantor of a historic augmented reality project
This is a first in Wallonia! The Citadelle de Dinant now offers an augmented reality tour that plunges visitors right into the heart of its history. At the helm: the French company Histovery, specializing in heritage reconstructions, with scientific support from Axel Tixhon, professor in the History Department at UNamur.
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Producing glass like the Romans: scientific research with a life-size experiment!
On 15 and 16 July, as part of the Gallo-Roman Rendezvous, the Specularia research project, run by the University of Namur and the Malagne Archaeopark, will be put through its paces in Malagne. This unique and exceptional experiment will give visitors a hands-on opportunity to discover what experimental archaeology is all about and to witness the different stages in the production of Roman window glass. This life-size experiment is part of the second phase of the Spécularia research project led by Géraldine Frère, a doctoral researcher in archaeology at the Institut Patrimoines, Transmissions, Héritages (PaTHs).
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Understanding the history of violence against women in Senegal: research wins ARES "Gender and Health" award
Angélique Aristondo, a C2W post-doctoral fellow at UNamur, has distinguished herself by winning the second 2023 Gender and Health Research Award from the ARES Women and Science Committee. Her research project focuses on violence against women in Senegal.
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Prostate cancer under the microscope
In 1996, the European Union created the Marie Skłodowska-Curie Actions (MSCA), a set of prestigious and competitive grants designed to fund research. Thanks to her, the PROSTAMET project got underway on January 1, an ambitious program focused on training PhD students and discovering new therapeutic avenues against prostate cancer, in which UNamur is participating.
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The "Même pas peur! between education, experience and commitment
The wolf, long banished from our lands, has made a remarkable comeback in Wallonia since 2016. This mysterious being, now protected, arouses as much fascination as fear. Through an exhibition, held as part of the Cultural Project course, third-year history bachelor students have traced the history of the wolf. From April 11 to 27, 2024, the exhibition entitled "Même pas peur! Une évolution de l'image du loup à travers les siècles" invited audiences to plunge into the heart of a historical exploration.
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Our researchers in the World's Top 2% Scientists list
Stanford University has published a prestigious ranking that highlights the most influential researchers in a wide range of scientific fields. The list, based on bibliographic criteria, aims to provide a standardized means of identifying the world's scientific leaders. It is one criterion among others for assessing the quality of scientific research. Twelve researchers from the University of Namur are among them!
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