Electronic structure and geometry of transition metal complexes
Structure-reactivity relationships in transition metal complexes
Reactivity of polar organometallics
Catalytic cycles involving transition metal complexes
Hydrogenation reactions
Cross-coupling reactions
CH activation reactions
The lecture is designed to give a first overview of the reactivity of transition metal complexes and their uses as catalysts.
A rational approach based on structure and reaction mechanisms is used.
The main families of transformations employing organometallics are reviewed and a structural and mechanistic approach is applied.
CHAPTER 1 : Polar organometallic reagents
CHAPTER 2 : Hydrometalation and carbometallation
CHAPTER 3 : Transition metal complexes
CHAPTER 4 : Cross-coupling reactions
CHAPTER 5 : Hydrogenations reactions
CHAPTER 6 : Alkenes metathesis
CHAPTER 7 : C-H activation reactions
Some exercises will be done during the lessons
A written examination of 2-3 hours based on recent publications that are handed out beforehand.
Course notes are provided in PDF format.
Additional reading:
Specialised books
R. H. Crabtree « The Organometallic Chemistry of the Transition Metals »
J. Tsuji « Transition Metal Reagents and Catalysts: Innovations in Organic Synthesis » ; « Palladium Reagents and Catalysts: Innovations in Organic Synthesis » ; « Palladium Reagents and Catalysts: New Perspectives for the 21st Century » ; « Palladium in Organic Synthesis »
M. Schlosser « Organometallics in Synthesis : A Manual »
L. S. Hegedus « Transition Metals in the Synthesis of Complex Organic Molecules »
Oxford Chemistry Primers:
P. R. Jenkins « Organometallic Reagents in Synthesis »
M. Bochmann « Organometallics 1 » ; Organometallics 2 »
N. N. Greenwood, A. Earnshaw « Chemistry of the Elements »
F. A. Cotton, G. Wilkinson « Advanced Inorganic Chemistry »
General books
J. Clayden, N. Greeves, S. Warren, P. D. Wothers « Organic Chemistry »
K. C. Nicolaou, E. J. Sorensen « Classics in Total Synthesis »
K. C. Nicolaou, S. A. Snyder « Classics in Total Synthesis II »
L. Kürti, B. Czakó « Strategic Applications of Named Reactions in Organic Synthesis »
Handbook of Functionalized Organometallics: Applications in Synthesis. Editor(s):. Prof. Paul Knochel
Organotransition Metal Chemistry: From Bonding to Catalysis : John Hartwig
| Training | Study programme | Block | Credits | Mandatory |
|---|---|---|---|---|
| Master in Chemistry | Standard | 0 | 4 | |
| Master in Chemistry | Standard | 0 | 4 | |
| Standard | 0 | 4 | ||
| Master in Chemistry | Standard | 1 | 4 | |
| Master in Chemistry | Standard | 1 | 4 | |
| Standard | 1 | 4 |