Learning outcomes

Mullier F :

Pharmacotherapy

George F :

Pharmacotherapy

D'Hondt L. :

Personalized medicine

 

Goals

Mullier F :

After the course, the students should be able to understand  the definition and the relevance of biomarkers

George F :

Biomarkers: After the course, the students should be able to understand  the definition and the relevance of biomarkers

Biobank: The program of this course provides key elements for reflection and support for the development of research projects. At the end of this course the students will know legislation and ethics rules to be taken into account to develop a research project as well as requirements in terms of quality ‘samples used

Personalized Medicine: At the end of this course, students will be able to understand the advantages and issues of setting up a personalized medicine

 

Content

Mullier F :

Definition

Different types of biomarkers

Development of one biomarker

Technologies

Genome sequencing

Proteomic (mass spectrometry)

Flow cytometry

Epigenetics

Interest of biomarkers: prognosis, diagnosis, follow the efficacy of one treatement

Examples :

  •        Epigenetics
  •        Microparticles --> biomarker of thrombotic disorders
  •        Minimal residual disease --> biomarker of hemorragic diseases
  •        miRNA --> biomarker of hematologic and cancer diseases
  •  ….

George F :

- Personalized medicine (D'Hondt L.) :

Introduction

Definition, objectives

Historical

What is new?

Preventive medicine

Predictive Medicine

Targeted Medicine

Biomarkers

Effective research

Health Care Control

Predictive tests

Authorities and companies

Refunds

Ethics

Privacy, confidentiality and patient rights

Examples

- Biobank (George F.) :

Definition, different types of biobanks, interests and issues, requirements (ethics, legislative, quality, management), importance of networking

- Biomarkers (Mullier F.) :

Definition

Different types of biomarkers

Development of one biomarker

Technologies

Genome sequencing

Proteomic (mass spectrometry)

Flow cytometry

Epigenetics

Interest of biomarkers: prognosis, diagnosis, follow the efficacy of one treatement

Examples :

  •        Epigenetics
  •        Microparticles --> biomarker of thrombotic disorders
  •        Minimal residual disease --> biomarker of hemorragic diseases
  •        miRNA --> biomarker of hematologic and cancer diseases
  •  ….

Assessment method

Mullier F :

Oral presentation by the students (review paper)

Presentations

Answers to the questions

George F-D'Hondt L. :

Biobank and biomarkers: oral exam (preparation time)

 Biomarkers: Oral presentation by the students (review paper)

                        Presentations

                        Answers to the questions

The exact modalities of the evaluation are likely to be modified during the preparation of the examination schedules, depending on the practical constraints with which the faculty administration may be confronted, or in the event of illness / force majeure / encroachment with an internship, or because of the health situation related to the coronavirus.

Language of instruction

Français