Search results

Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

From 11 to 13 May 2022, a hundred or so scientists and actors from the economic and cultural world gathered at UNamur to discuss the issue of water pollution. The aim? To share and enrich knowledge, but also to alert and inform about its long-term effects on fauna, flora and human beings. Scientific sessions, workshops and a conference for the public were on the programme for these three days.

His long-term collaboration with Dr. Aniruddha Chatterjee recently resulted in the first collaborative framework agreement between the University of Otago and UNamur, as well as an international Erasmus+ (EU) credit mobility funding this scientific mission. Frédéric Silvestre deepened his understanding of the advanced DNA methylation techniques employed by Dr. Chatterjee's team, including their bioinformatics workflows and innovative approach to epigenetic editing. He has given several seminars presenting LEAP's research on mangrove rivulus and turquoise molefish. He also presented at the Australasian Epigenetic Alliance conference and had the opportunity to explore potential new collaborations with other departments, including zoology, sustainable development, chemistry and marine sciences.

The two authors will each read an excerpt from their book, then explain their choice to explore the themes of foot travel, nature and memory in their works. This reading will be followed by a discussion during which the audience and our students will be able to ask questions.This event aims to establish links between our research in "embodied cognition", cognitive narratology and travel literature, and our teaching activity. It will enable us to offer our students a bilingual activity while promoting the teaching and study of literature at UNamur and within the NaLTT Institute. We hope to invite interested researchers and their students via our respective networks. With this theme, we will also fit in with UNamur's ecological and pedagogical objectives.

Program 5-6pm: Student read-aloud6-7:30pm: Lecture by Julia Kerninon7:30pm-9pm: DrinkConference and performance aimed at students but open to all, interns and externs. Free but reservation required (aurelie.sinte@unamur.be)

Located in the Indian Ocean, Madagascar is an island with a rich natural heritage and multiple cultural influences. For over 15 years, researchers from the University of Namur have been working with a number of Madagascan universities and institutes on a variety of themes, including environmental preservation, water management and institutional capacity building. Focus on some of these projects.

Researchers from UNamur's Departments of Biology and Physics have conducted a scientific experiment to assess the radioresistance of the common black ant Lasius niger. The results of their work have just been published in the Belgian scientific journal Belgian Journal of Zoology. The Namur-based scientists demonstrate a level of resistance far superior to that of humans. Their spontaneous approach also demonstrates a lesser-known approach to scientific research.

In a new publication, the European Reference Genome Atlas (ERGA) announces the success of its pilot project. This pioneering initiative has brought together a vast collaborative network of researchers and institutions in 33 countries to produce high-quality reference genomes of 98 European species. This continental effort paves the way for a new, inclusive and equitable model of biodiversity genomics.

Space has become a major economic and strategic issue. As a member of the European UNIVERSEH Alliance, UNamur explores this space theme in its various departments, from physics to geology, via mathematics, computer science or philosophy. Without forgetting to address the general public, who still dream of the stars...

The colloquium will be held on Tuesday, April 15 and Wednesday, April 16, 2025, at the University of Namur (Belgium). Proposals for papers (programmatic title and abstract of 500 signs, followed by a biobibliography) can be sent by November 15, 2024 to Jean-Benoit.Gabriel@unamur.be and Denis.Saint-Amand@unamur.be.

Two researchers at the Institut du Langage, du Texte et de la Transmédialité (NaLTT) have just been awarded funding from the F.R.S - FNRS following calls whose results were published in December 2024.Composed of researchers in linguistics and literature, the NaLTT Institute constitutes an interdisciplinary space for diachronic and synchronic research into verbal and multimodal communicative practices that manifest themselves in, are shaped and/or regulated by culture and society.

From March 31 to April 4, 2025, a Belgian delegation, including UNamur Rector Annick Castiaux, took part in a royal mission to Vietnam aimed at strengthening economic, academic and scientific ties between the two countries. The mission was punctuated by several milestone events highlighting UNamur's fruitful collaborations with Vietnamese institutions.