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Target audienceGeneral practitioners (in practice or in training)PharmacistsMedical and pharmacy studentsObjectivesShare and discuss scientific articles relevant to frontline practice in a friendly and caring atmosphereStrengthen skills in critical reading and evidence-based medicineCreate a lasting link between the field and the academic worldFederate an active and committed medico-pharmaceutical community.pharmaceutical communityWhy participate?Because science moves fast, and we all benefit from taking the time to read, understand, and question the literature together. Because quality care starts with shared reflection. And because it's the ideal opportunity to strengthen bridges between disciplines.Location and frequency of meetingsUNamur - Quai22 - 2 times a yearFirst meeting: 5/06/2025 (free with registration)INAMI accreditation required. I want to register

Beautiful victory for Margaux Mignolet, a researcher at the Faculty of Medicine's Unité de Recherche en Physiologie Moléculaire (URPhyM), who wins 1st prize in the Belgian inter-university final of the Ma thèse en 180 secondes (MT180) competition. Her research? To better understand the mechanisms of antibodies active in cases of long COVID. The second prize in this national competition was also won by a candidate from Namur. It was Petra Manja, from the Unité de Recherche en biologie des micro-organismes (URBM), Department of Biology, Faculty of Science, and is pursuing a thesis aimed at understanding resistance mechanisms in the bacterium E. coli. Both are also researchers at the NARILIS Institute.

Abstract Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect-termed the FLASH effect-remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its efficacy in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PresidentProf. Stéphane LUCAS (UNamur), SecretaryProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (University of Bern)Dr Rudi LABARBE (IBA)

Hepatocellular carcinoma is the most common primary liver cancer. Unfortunately, this tumor still has a high mortality rate due to the lack of effective treatments for its most advanced or poorly localized forms. As part of a partnership with the CHU UCL Namur - site de Godinne and with the support of Roche Belgium, researchers in the Department of Biomedical Sciences are trying to understand why liver tumor cells are so resistant to treatment, and to identify therapeutic alternatives to better target them.

On May 10, 2025, Vice-Rector Carine Michiels and Professor Anne-Catherine Heuskin handed over UNamur's cheque at the grand closing evening of Operation Télévie, which this year raised a record €13,351,977 for the Fonds National de la Recherche Scientifique. Télévie funds are used entirely to finance cancer research projects at universities in the Wallonia-Brussels Federation and the Grand Duchy of Luxembourg.

Researchers at the Universities of Namur (UNamur), Brussels (ULB) and Liège (ULiège) have just taken a key step towards understanding viral mechanisms. Their study, published in the international scientific journal PLOS Pathogens, focuses on a particular type of molecule produced by viruses, circular RNAs, and presents an innovative bioinformatics tool capable of better identifying them.

Abstract Primarily described as an alarmone, secondary messenger (p)ppGpp, when accumulated, binds to many targets involved in DNA replication, translation, and transcription. In the asymmetrically-dividing a-proteobacterium Caulobacter crescentus, (p)ppGpp has been shown to strongly impact cell cycle progression and differentiation, promoting the non-replicating G1/swarmer phase. Mutations in the major subunits of transcriptional complex, b or b' subunits, were able to display the (p)ppGpp-related phenotypes even in the absence of the alarmone. We identified that the transcriptional holo-enzyme, RNA polymerase (RNAP) is a primary target of (p)ppGpp in C. crescentus. Furthermore, mutations that inactivate (p)ppGpp binding to RNAP annihilated the (p)ppGpp-related phenotypes and phenocopied a (p)ppGpp0 strain. Our RNAseq analysis further elucidated the changes in the transcriptional landscape of C. crescentus cells displaying different (p)ppGpp levels and expressing RNAP mutants. Since the DNA replication initiation protein DnaA is required to exit the G1 phase, we observed that it was significantly less abundant in cells accumulating (p)ppGpp. We further explored its proteolysis under the influence of (p)ppGpp. Our work suggests that (p)ppGpp regulates cell cycle and differentiation in C. crescentus by reprogramming transcription and triggering proteolytic degradation of key cell cycle regulators by yet unknown mechanisms. In Part II, we identified two σ factors belonging to the ECF family that might be involved in this (p)ppGpp-accompanied phenotypes. In Part III, we propose an overlapping role of the ω subunit, RpoZ, and the heat shock subunit, RpoH, in carbon metabolism.JuryProf. Gipsi LIMA MENDEZ (UNamur), PresidentProf Régis HALLEZ (UNamur), SecretaryDr Emanuele BIONDI (CNRS-Université Paris-Saclay)Prof. Justine COLLIER (University of Lausanne)Dr Marie DELABY (Université de Montréal)

Abstract Estrogens originating from human and animal excretion, as well as from anthropogenic sources such as cosmetics, plastics, pesticides, detergents, and pharmaceuticals, are among the most concerning endocrine-disrupting compounds in aquatic environments due to their potent estrogenic activity. While their effects on fish reproduction are well documented, their impact on development, particularly metamorphosis, remains poorly studied. This hormonal transition, mainly controlled by the thyroid axis, is essential for the shift from the larval to the juvenile stage in teleosts.The effects of two contraceptive estrogens on zebrafish (Danio rerio) metamorphosis were evaluated: 17α-ethinylestradiol (EE2), a synthetic reference estrogen, and estetrol (E4), a natural estrogen recently introduced in a new combined oral contraceptive formulation. Continuous exposure from fertilization to the end of metamorphosis allowed the assessment of morphological changes, disruptions of the thyroid axis, and modifications of additional molecular pathways potentially involved in metamorphic regulation.EE2 induced significant delays and disturbances in metamorphosis, affecting both internal and external morphological traits, confirming its role as an endocrine disruptor of concern. In contrast, E4 did not cause any detectable morphological alterations even at concentrations far exceeding those expected in the environment, indicating a limited ecotoxicological risk. Molecular analyses showed that EE2 strongly affected thyroid signaling and energy metabolism during metamorphosis, whereas E4 induced only minor transcriptional and proteomic changes.This study provides the first evidence that EE2 can disrupt zebrafish metamorphosis and highlights the importance of including this developmental stage in ecotoxicological assessments. The results also suggest a larger environmental safety margin for E4, although further research is needed to clarify the mechanisms linking estrogen exposure to metamorphic regulation.JuryProf. Frederik DE LAENDER (UNamur), PresidentProf. Patrick KESTEMONT (UNamur), SecretaryDr. Sébastien BAEKELANDT (UNamur)Dr. Valérie CORNET (UNamur)Prof. Jean-Baptiste FINI (Muséum National d'Histoire Naturelle, Paris)Dr. Marc MULLER (ULiège)Prof. Veerle DARRAS (KULeuven)

Program FEBRUARY 139.00-9.30 Registration Auditorium E13Chair: Jean-Marie Baland9.30-10.15 Catherine Guirkinger (University of Namur) - Height, parental investments and marriage payments in sub-Saharan Africa10.15-11 Clément Imbert (Sc Pos Paris) - Dry Lives: Climate Adaptation and Mortality in the Semi-arid Regions of Brazil 11-11.30 coffee break11.30-12.15 Karlijn Morsink (Utrecht University) - Keeping the Peace while Getting Your Way: Information, Persuasion and Intimate Partner Violence12.15-13.00 Liam Wren-Lewis (Paris School of Economics) - Decentralization, Ethnic Fractionalization, and Public Services: Evidence from Kenyan Healthcare 13.00-14.10 Lunch Break and EC MeetingChair: Guilhem Cassan14.15-15.00 Christelle Dumas (University of Fribourg) Informal labor exchange teams and participation on the labor market: Evidence from rural Tanzania15.00-15.45 Andreas Madestam (University of Stockholm) Credit Contracts, Business Development and Gender: Evidence from Uganda15.45-16.15 Coffee Break16.15-17.00 Salvatore di Falco (University of Geneva) Farming, Non-Farm Enterprise, and Migration Under Incomplete Markets17:00-17:45 Jadnith Kaur (University of Glasgow) How Much Do I Matter? Teacher Self-Beliefs, Effort, and Education Production18:15 EUDN General Assembly 19.30 Conference DinnerFEBRUARY 14Chair: Sylvie Lambert9.30-10.15 Yannick Dupraz (University of Paris Dauphine) A century of language and migration in India10:15-11:00 Laura Montebruck (Stockholm University) Fiscal exchange and Tax Compliance: Strengthening the the Social Contract Under Low State Capacity 11-11.30 coffee break11.30-12.15 Justine Knebelmann (Sciences Po, Paris) Discretion versus Algorithms: Bureaucrats and Tax Equity in Senegal12.15-13.00 Imelda (Geneva Graduate Institute) Crime in the Dark: Role of Electricity Rationing 13.00-14.00 Lunch BreakChair: Catherine Guirkinger14.00-14:45 Rieger Matthias (Erasmus School of Health Policy & Management, Rotterdam) Shaken, not Stunted? Global Evidence on Natural Disasters, Child Growth and Recovery14.45-15:30 Guilhem Cassan (University of Namur) Political Determinants of the News Market: Novel Data and Quasi-Experimental evidence from India 15.45 End of the Conference Full program

On the occasion of the International Day of Women and Girls in Science proclaimed on February 11 by the United Nations General Assembly, and as part of the European alliance European Space University for Earth and Humanity (UNIVERSEH) focusing on the theme of space, discover the testimonies of four women scientists from UNamur working on astronomical themes.

In an ever-changing world, where health, environmental and societal crises are intertwined, it is becoming imperative to rethink health in a global and interconnected approach. It was against this backdrop that the Faculty of Medicine at the University of Namur inaugurated its new "One Health" teaching unit (UE) on Thursday February 06, 2025, in the presence of Minister Yves Coppieters. This initiative, offered to all UNamur undergraduates, aims to train tomorrow's healthcare professionals in a systemic vision, where human, animal and environmental health are considered as one and the same reality.

Helping us to age independently and in good health. This is the aim of Charlotte Beaudart's research into sarcopenia, an age-related disease that can occur as early as the age of 50. The work of the UNamur researcher and member of the Narilis Institute has been rewarded once again, as she has just been awarded the title of "Namuroise of the Year", for the Sciences category!