The chapters covered in this course focus on the fundamental molecular and cellular mechanisms of the most common neurodegenerative diseases (Alzheimer's, Parkinson's, ALS, IBS, lysosomal or mitochondrial diseases, demyelinating diseases), rather than on their clinical/diagnostic/therapeutic presentations. The first two lectures will lay the neuroanatomical and cellular foundations needed to understand the CNS and the main pathophysiological mechanisms associated with neurodegeneration (protein aggregation, protein dissemination, neuroinflammation, oxidative stress, mitochondrial or lysosomal defects, axo-plasmic transport, excitotoxicity, etc.). These mechanisms will be placed in the context of selected neurodegenerative diseases. The mechanistic specificities of each disease and elements of genetics will be integrated into the teaching.
None
The examination consists of an oral presentation of a scientific article and a written paper summarising the main results of the study and offering a critical view and perspectives by the student.
| Training | Study programme | Block | Credits | Mandatory |
|---|---|---|---|---|
| Master in Biology | Standard | 0 | 3 | |
| Master in Biochemistry and Molecular and Cell Biology, Teaching focus | Standard | 0 | 3 | |
| Master in Biochemistry and Molecular and Cell Biology, Professional focus | Standard | 0 | 3 | |
| Master in Biochemistry and Molecular and Cell Biology, Research focus | Standard | 0 | 3 | |
| Master in Biochemistry and Molecular and Cell Biology, Teaching focus | Standard | 1 | 3 | |
| Master in Biochemistry and Molecular and Cell Biology, Professional focus | Standard | 1 | 3 | |
| Master in Biochemistry and Molecular and Cell Biology, Research focus | Standard | 1 | 3 | |
| Master in Biology | Standard | 1 | 3 |