Learning outcomes

The chapters in this course focus on the basic molecular and cellular mechanisms of the most common neurodegenerative diseases (Alzheimer's, ALS, IBS, Parkinson's, lysosomal or mitochondrial diseases, demyelinating diseases), rather than on their clinical/diagnostic/therapeutic presentations. The first two courses will provide the neuroanatomical and cellular basis for understanding the CNS and the main pathophysiological mechanisms related to neurodegeneration (protein aggregation, protein dissemination, neuroinflammation, oxidative stress, mitochondrial or lysosomal defects, axo-plasmic transport, excitotoxicity, ...). These mechanisms will be put into the context of selected neurodegenerative diseases. The mechanistic specificities of each disease as well as elements of genetics will be integrated into the teaching. I hope that this teaching will be complementary to the optional course SBIOM210 offered in MA2 BBMC.

Goals

To understand the pathophysiology of certain neurological and neurodegenerative diseases, focusing on the mechanisms and molecular aspects known to date and their experimental approaches.

Content

Introduction to Neuroanatomy Basics of Neuropathology Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis Spinal cord injury Multiple sclerosis and other demyelinating diseases

Table of contents

Introduction to neuroanatomy Notions of neuropathology Alzheimer's disease Parkinson's disease Huntington's disease Amyotrophic Lateral Sclerosis Spinal cord injuries Multiple sclerosis and other demyelinating diseases

Exercices

None

Assessment method

The examination consists of an oral presentation of an original scientific article and a written paper summarising the main results of the study and the perspectives proposed by the student.

Language of instruction

Anglais