In Walloon Region, the industrial network mainly consists of Small and Medium size Enterprises (99.5%) whose innovation approach is based on intrapreneurship rather than on a causal approach typical of large companes where the management of technology and financial risks is the rule. The VIANEO method, developed by Séverine Herlin in 2008, offers solutions for the management of innovative breakthrough projects, such as those carried out within our University, focusing on the search for Excellence, the question of market access strategy through differentiating advantage, the identification of painful needs and supportive network of economic actors and influencers. Among differentiating advantage, protection of Intellectual Property through patents, designs and models, trademarks or software is key. The path is always exciting and access to tools such as VIANEO, proof of concept project (POC), technology transfers or creation of spin-offs (Win4SO) are assets for the University's research entrepreneurs.