The Elongator complex is involved in the addition of 5'-carboxylmethyluridine (cm5U)-derived modifications to transfer RNAs (tRNAs), thereby influencing the translation of certain messenger RNAs (mRNAs) and helping to maintain the integrity of the proteome. This complex is involved in a variety of biological processes, and is of particular importance in oncology. The identification of chemical inhibitors of Elongator is of significant interest in both basic and pharmaceutical research.

Through a yeast screen, this work reveals a potential new role for Elongator and identifies a chemical inhibitor of the complex. This compound presents itself as an interesting candidate as a pharmacological inhibitor, opening up new perspectives for the search for anti-cancer therapies.