Learning outcomes

Upon completion of this course, students will have gained the theoretical bases of pharmacogenetics and will have become aware of the importance of genetic variation in the clinical response to drug treatments.

Goals

This course aims to present the basic concepts of pharmacogenetics, from which students will be able to understand the impact of the genome variation in the clinical response to treatments. Numerous examples of current practice will then be discussed, taking from pharmacokinetics and pharmacodynamics, the lack of efficacy and undesired effects, according to the discussed cases. Students will be asked to reflect about the best use of pharmacogenetics assays from the biomedical and the medical point of views, and to include these approaches in the personalized medicine context and its ethical aspects.

Content

Prof. Gillet:

  1. Basic concepts of pharmacogenetic
  2. Genotyping methods
  3. The role of transportome in treatment response

Prof. Flamion:

  1. Historic of the pharmacogenetics approach
  2. CYP2D6 polymorphisms, typical example
  3. Individual response to treatment
  4. Cancer pharmacogenomic
  5. Personalized medicine
  6. Ethical and societal aspects

Table of contents

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Exercices

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Assessment method

Students, by group of two, present an analysis of a research article.

Sources, references and any support material

PowerPoint presentations, textbook of practicals, research and review articles.

Language of instruction

Français
Training Study programme Block Credits Mandatory
Standard 0 2
Standard 0 2
Standard 0 2
Standard 0 2
Standard 0 2
Standard 0 2
Standard 1 2
Standard 2 2
Standard 2 2
Standard 2 2
Standard 2 2
Standard 2 2