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Networks are fundamental to the modelling of complex systems, systems composed of an incredibly large number of interacting parts. Applications are numerous, in neuroscience, epidemiology, but also in computer science and engineering. A collaboration between the University of Catania (Italy) and the University of Namur, led by Professor Timoteo Carletti of the Department of Mathematics (naXys Institute), has developed a new formalism that allows the modelling of systems where several parts interact at the same time (multi-body) and in an asymmetric way. This research has been published in the prestigious journal Communication Physics, part of the Nature group.

Let's go and discover the qualified researchers of UNamur, winners of the funding granted by the FNRS in 2022. Today, we meet Michaël Lobet, currently a lecturer at UNamur, who will begin his new mandate as a qualified FNRS researcher at the NISM Institute next fall. The subject of his research: twisted optics for the manipulation of slow photons or how to create light traps. Explanations.

An international team of physicists led by Dr Michaël Lobet, lecturer at UNamur, re-examines the foundations of quantum physics from the point of view of momentum in the prestigious journal Nature Light Science & Applications. The researchers investigated what happens when this momentum is reduced to zero. Some interesting things happen! Explanations.

Prof. Olivier Deparis and Dr Sébastien Mouchet (University of Namur, NISM Institute, Department of Physics) have published a book on the theme of physical optics and environmental biology. On the path of Jean-Pol Vigneron’s research, this “avant-garde” book according to Artech House, opens the door to bioinspired applications in the fields of optics, energy and the environment. Explanation.

From 17 April 2023, UNamur will host two prestigious international Francqui Chairs. Professor Timoteo Carletti (Department of Mathematics - naXys Institute) will host Professor Ginestra Bianconi, one of the leading experts on networks and high-order structures. Professor Romain Houssa (Faculty of Economics, Social Sciences and Management - DeFiPP Institute) will welcome Professor Karel Mertens, an expert in macroeconomics.

On 9 June 2023, the NISM and naXys Institutes, the Physics and Chemistry Departments and the Namur Research College were delighted to welcome Prof. Jean-Luc Brédas from the University of Arizona. A prestigious speaker of international renown, Prof. Brédas completed his doctoral thesis with Prof. Jean-Marie André at the University of Namur.

Japan is almost 10,000 kilometers from Belgium, a country that fascinates, not least for its rich culture full of contrasts. Researchers at UNamur maintain close ties with several Japanese institutions, particularly in the fields of computer science, mathematics and video games. Let's take a look at some of these collaborations..

In early September, the University of Namur hosted the first Main-Group Elements Reactivity Conference (MG-ERC). Over 100 researchers from 12 countries and 32 institutions gathered around Professor Guillaume Berionni. An event hailed as "one of the best chemistry conferences" by its prestigious guests.

A team of American researchers, with the help of Frédérik De Laender, professor in the Department of Biology at UNamur, has just published in the prestigious journal Nature. Their study describes how changing stream temperatures and human introductions of fish can alter river biodiversity in the USA.

Initiated in 1969 by Pullmann and Del Re, the congress is an annual meeting to promote collaboration and friendship between Latin-speaking theoretical chemists. In its early years, European researchers were the main contributors. Subsequently, the Latin American community has made a major contribution, with the emergence of teams whose international reputation now extends far beyond our own community.We are delighted to be holding this meeting at the University of Namur, 55 years after the first CHITEL was organised in Paris, France. We are sure that this 2024 edition will once again be an opportunity to take advantage of the good humour and dynamism of Latin to encourage, develop and strengthen scientific exchanges.We look forward to welcoming you at the University of Namur,The CHITEL 2024 Local Organising Committee. Website

Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

Abstract Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect-termed the FLASH effect-remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its efficacy in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PresidentProf. Stéphane LUCAS (UNamur), SecretaryProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (University of Bern)Dr Rudi LABARBE (IBA)