Learning outcomes

At the end of the course, the student will be able to explain the interaction of a drug with the human body and determine the pharmacokinetic properties of a drug.

Goals

To integrate the concepts of biochemistry, physiology, signal transduction and ligand binding to receptors.

Content

• Course. 1. Introduction - Basic concepts 2. Pharmacokinetics 3. Pharmacodynamics 4. Special pharmacology • Tutorial. TD1 • Basics of pharmacokinetics • Passive diffusion (pH/pka) • Bolus IV in a single or bi-compartmental model TD2 Repeated Doses (RD) and Slow Infusion (specific to IR and HI) TD3 Converting in vitro clearance (CL) from a metabolism model to the individual's liver CL TD4 PK (PharmacoKinetic) and PD (PharmacoDynamic) studies in special populations. • Newborn • Child • Pregnant/lactating woman • Elderly person

Assessment method

Written examination assessing theory and exercises based on open questions, True/False questions and exercises. The distribution of the mark is as follows: - The chapters Introduction, Pharmacodynamics and Special Pharmacology are graded /10 - The Pharmacokinetics chapter and the tutorials are graded /10.

Sources, references and any support material

The PowerPoint slideshow, the practical booklet, and the research and review articles that support the study are available on Webcampus. General and Molecular Pharmacology (Edited byClementi & Fumagalli), WILEY Pharmacology (Edited by Hacker, Bachman, Messer), Elsevier-Academic Press Pharmacologie (Edited by Landry & Gies), Dunod

Language of instruction

English