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Lately, and thanks to LUMI, one of Europe's largest supercomputers, the limits of our knowledge of cell lipid membranes have been pushed back. A team of Namur researchers, including Professor Benoît Champagne and Drs. Pierre Beaujean and Charlotte Bouquiaux, has just published in the Journal of Chemical Information and Modeling. The results of this study pave the way for new approaches in the field of membrane lipid therapy.

One year after receiving funding from the European Research Council (ERC) for his B-Yond project, Prof Guillaume Berionni has just been named a Fellow of the prestigious European chemistry society Chemistry Europe. This distinction makes him the new representative for Belgium for a period of 2 years.

On 21 and 22 September 2023, for the 4th year running, Belgian researchers came together for the bePOM conference. The format was original, with a virtual day and a hybrid day combining virtual and face-to-face sessions. A great success, and a Belgian network that is growing from strength to strength.

The absorption of light by molecules has applications in microscopy, medicine and data storage. With this research, the researcher from the UNamur NISM institute fills an experimental gap, which will enable molecular engineers to develop new and more efficient compounds in their various fields of application.

Yves Caudano, F.R.S.-FNRS qualified researcher, member of the NaXys and NISM Institutes and the UR-LLS (Lasers and Spectroscopies Laboratory) research unit, is taking part in a major European research project. The aim? To find new quantum light sources with unprecedented versatility, flexibility and performance.

An international group of researchers, including Professor Yoann Olivier from the NISM Institute at UNamur, has just published in the prestigious journal Nature. The subject: understanding the microscopic mechanisms that lead to the initialisation, reading and erasing of molecular qubits, a new theme in the study of materials, at the frontier between physics and chemistry.

On 13 December 2023, Charlotte Beaudart, a new academic at the University of Namur Faculty of Medicine, will be awarded a prize at the annual ceremony for Belgian scientific research in support of her innovative research on the subject of ageing.

Dr. Sébastien Mouchet, a researcher at UNamur and member of the NISM and ILEE Institutes, has just published the results of research focusing on the effects of pollution on coral reef fish in MDPI-Optics. The findings of the international, multidisciplinary team lead to crucial conclusions with implications for the health of marine ecosystems.

The Elongator complex is involved in the addition of 5'-carboxylmethyluridine (cm5U)-derived modifications to transfer RNAs (tRNAs), thereby influencing the translation of certain messenger RNAs (mRNAs) and helping to maintain the integrity of the proteome. This complex is involved in a variety of biological processes, and is of particular importance in oncology. The identification of chemical inhibitors of Elongator is of significant interest in both basic and pharmaceutical research.Through a yeast screen, this work reveals a potential new role for Elongator and identifies a chemical inhibitor of the complex. This compound presents itself as an interesting candidate as a pharmacological inhibitor, opening up new perspectives for the search for anti-cancer therapies.

Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

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Initiated in 1969 by Pullmann and Del Re, the congress is an annual meeting to promote collaboration and friendship between Latin-speaking theoretical chemists. In its early years, European researchers were the main contributors. Subsequently, the Latin American community has made a major contribution, with the emergence of teams whose international reputation now extends far beyond our own community.We are delighted to be holding this meeting at the University of Namur, 55 years after the first CHITEL was organised in Paris, France. We are sure that this 2024 edition will once again be an opportunity to take advantage of the good humour and dynamism of Latin to encourage, develop and strengthen scientific exchanges.We look forward to welcoming you at the University of Namur,The CHITEL 2024 Local Organising Committee. Website