Electronic structure and geometry of transition metal complexes
Reaction mechanisms of organometallic compounds (cross-coupling reactions, CH activation reactions...)
Structure-reactivity relationships in transition metal complexes
Reactivity of polar organometallics
Catalytic cycles involving transition metal complexes
The lecture is designed to give a first overview of the reactivity of transition metal complexes. A rational approach based on structure and reaction mechanisms is used.
The main families of transformations employing organometallics are reviewed and a structural and mechanistic approach is applied.
1. Introduction
2. Reaction mechanisms
3. Polar organometallics
4. Hydrometallation reactions of multiple bonds
5. Carbometallation reactions of multiple bonds
6. Hydrogenation of double bonds
7. Pd-mediated C-C coupling reactions
8. C-N and C-O coupling reactions
9. Allylic substitutions
10. Addition of nucleophiles to multiple bonds
11. Carbophilic activation of multiple bonds by gold and platinum
12. Chemistry of Schrock carbenes
Supplementary exercises are available online.
A written examination in which all documents are allowed and which is based on recent publications that are handed out beforehand.
Course notes are provided in PDF format.
Additional reading:
Specialised books
R. H. Crabtree « The Organometallic Chemistry of the Transition Metals »
J. Tsuji « Transition Metal Reagents and Catalysts: Innovations in Organic Synthesis » ; « Palladium Reagents and Catalysts: Innovations in Organic Synthesis » ; « Palladium Reagents and Catalysts: New Perspectives for the 21st Century » ; « Palladium in Organic Synthesis »
M. Schlosser « Organometallics in Synthesis : A Manual »
L. S. Hegedus « Transition Metals in the Synthesis of Complex Organic Molecules »
Oxford Chemistry Primers:
P. R. Jenkins « Organometallic Reagents in Synthesis »
M. Bochmann « Organometallics 1 » ; Organometallics 2 »
N. N. Greenwood, A. Earnshaw « Chemistry of the Elements »
F. A. Cotton, G. Wilkinson « Advanced Inorganic Chemistry »
General books
J. Clayden, N. Greeves, S. Warren, P. D. Wothers « Organic Chemistry »
K. C. Nicolaou, E. J. Sorensen « Classics in Total Synthesis »
K. C. Nicolaou, S. A. Snyder « Classics in Total Synthesis II »
L. Kürti, B. Czakó « Strategic Applications of Named Reactions in Organic Synthesis »